VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

HighTower Advisors, LLC's Holding History (CIK: 0001462245)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 47,559 Value ($000) $21,561 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 44,015 Value ($000) $17,238 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 56,347 Value ($000) $25,086 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 53,625 Value ($000) $25,999 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 48,586 Value ($000) $19,566 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 57,242 Value ($000) $26,494 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 53,094 Value ($000) $24,724 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 57,286 Value ($000) $23,978 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 82,449 Value ($000) $33,425 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 88,494 Value ($000) $30,683 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 83,941 Value ($000) $29,510 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 61,023 Value ($000) $19,272 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 63,828 Value ($000) $18,428 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 49,959 Value ($000) $14,477 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 57,807 Value ($000) $16,310 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 94,309 Value ($000) $24,629 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 64,863 Value ($000) $14,200 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 53,658 Value ($000) $9,693 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 13,384 Value ($000) $2,693 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 15,635 Value ($000) $3,363 Avg Close $219.65 Range $204.62 - $242.99

Q3 2020

Shares 13,185 Value ($000) $3,590 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 11,379 Value ($000) $3,305 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 9,969 Value ($000) $2,379 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 10,162 Value ($000) $2,225 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 8,660 Value ($000) $1,470 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 6,702 Value ($000) $1,231 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 5,532 Value ($000) $1,015 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 6,898 Value ($000) $1,135 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 10,281 Value ($000) $1,988 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 6,984 Value ($000) $1,185 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 6,710 Value ($000) $1,092 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 8,056 Value ($000) $1,203 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 15,987 Value ($000) $2,433 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 18,975 Value ($000) $2,447 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 18,387 Value ($000) $2,012 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 6,718 Value ($000) $495 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 8,554 Value ($000) $748 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 2,894 Value ($000) $252 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 6,720 Value ($000) $532 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 11,068 Value ($000) $1,395 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 3,554 Value ($000) $369 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 7,727 Value ($000) $954 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 22,621 Value ($000) $2,668 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 31,457 Value ($000) $3,737 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 57,007 Value ($000) $6,402 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 58,880 Value ($000) $5,575 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 58,549 Value ($000) $4,141 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 5,753 Value ($000) $427 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 4,598 Value ($000) $349 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 4,044 Value ($000) $324 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	47,559	$21,561	$431.03	$392.50 - $464.44
Q3 2025	44,015	$17,238	$417.92	$362.50 - $484.56
Q2 2025	56,347	$25,086	$460.83	$416.60 - $510.77
Q1 2025	53,625	$25,999	$466.00	$397.25 - $519.68
Q4 2024	48,586	$19,566	$463.53	$377.85 - $519.88
Q3 2024	57,242	$26,494	$480.37	$456.07 - $510.64
Q2 2024	53,094	$24,724	$434.05	$391.01 - $486.43
Q1 2024	57,286	$23,978	$422.74	$403.43 - $448.40
Q4 2023	82,449	$33,425	$369.42	$341.85 - $413.00
Q3 2023	88,494	$30,683	$349.73	$335.82 - $367.00
Q2 2023	83,941	$29,510	$336.94	$313.47 - $354.94
Q1 2023	61,023	$19,272	$299.93	$282.21 - $325.19
Q4 2022	63,828	$18,428	$304.77	$283.58 - $324.75
Q3 2022	49,959	$14,477	$287.72	$271.61 - $305.95
Q2 2022	57,807	$16,310	$267.66	$233.01 - $293.17
Q1 2022	94,309	$24,629	$237.33	$214.66 - $263.58
Q4 2021	64,863	$14,200	$194.45	$176.36 - $224.49
Q3 2021	53,658	$9,693	$195.24	$180.02 - $204.88
Q2 2021	13,384	$2,693	$209.17	$185.33 - $222.78
Q1 2021	15,635	$3,363	$219.65	$204.62 - $242.99
Q3 2020	13,185	$3,590	$275.88	$253.97 - $306.08
Q2 2020	11,379	$3,305	$271.12	$222.39 - $299.21
Q1 2020	9,969	$2,379	$229.39	$197.47 - $249.85
Q4 2019	10,162	$2,225	$202.38	$165.23 - $225.66
Q3 2019	8,660	$1,470	$176.91	$165.27 - $188.44
Q2 2019	6,702	$1,231	$174.82	$163.68 - $191.71
Q1 2019	5,532	$1,015	$184.70	$160.95 - $195.81
Q4 2018	6,898	$1,135	$173.27	$151.80 - $194.92
Q3 2018	10,281	$1,988	$178.07	$164.70 - $193.78
Q2 2018	6,984	$1,185	$155.01	$144.07 - $172.00
Q1 2018	6,710	$1,092	$163.34	$146.21 - $178.15
Q4 2017	8,056	$1,203	$148.07	$136.50 - $158.04
Q3 2017	15,987	$2,433	$150.51	$125.50 - $167.86
Q2 2017	18,975	$2,447	$120.38	$107.24 - $137.26
Q1 2017	18,387	$2,012	$88.04	$73.34 - $111.88
Q4 2016	6,718	$495	$81.37	$71.46 - $97.93
Q3 2016	8,554	$748	$94.50	$83.50 - $103.73
Q2 2016	2,894	$252	$86.41	$75.92 - $96.49
Q1 2016	6,720	$532	$90.45	$75.90 - $124.96
Q4 2015	11,068	$1,395	$120.72	$101.49 - $134.71
Q3 2015	3,554	$369	$128.47	$97.45 - $143.45
Q2 2015	7,727	$954	$125.98	$113.68 - $137.50
Q1 2015	22,621	$2,668	$119.81	$103.75 - $136.33
Q4 2014	31,457	$3,737	$112.63	$96.43 - $124.35
Q3 2014	57,007	$6,402	$95.21	$84.41 - $116.88
Q2 2014	58,880	$5,575	$70.12	$59.79 - $98.80
Q1 2014	58,549	$4,141	$79.20	$67.49 - $87.77
Q4 2013	5,753	$427	$69.64	$58.06 - $78.38
Q3 2013	4,598	$349	$79.58	$73.43 - $89.96
Q2 2013	4,044	$324	$73.64	$51.28 - $87.47