VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Artisan Partners Limited Partnership's Holding History (CIK: 0001466153)

Note: Option positions (PUT/CALL) are excluded.

Q2 2025

Shares 650,259 Value ($000) $289,495 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 719,131 Value ($000) $348,649 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 664,523 Value ($000) $267,603 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 550,273 Value ($000) $255,921 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 515,386 Value ($000) $241,572 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 552,882 Value ($000) $231,110 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 576,507 Value ($000) $234,575 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 585,841 Value ($000) $203,720 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 639,796 Value ($000) $225,151 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 641,555 Value ($000) $202,135 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 188,470 Value ($000) $54,426 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 227,704 Value ($000) $65,929 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 378,580 Value ($000) $106,680 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 474,393 Value ($000) $123,802 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 462,314 Value ($000) $101,524 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 465,031 Value ($000) $84,352 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 466,109 Value ($000) $93,982 Avg Close $209.17 Range $185.33 - $222.78

Q3 2020

Shares 45,582 Value ($000) $12,404 Avg Close $275.88 Range $253.97 - $306.08

Q3 2015

Shares 60,637 Value ($000) $6,315 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 58,748 Value ($000) $7,254 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 59,052 Value ($000) $6,966 Avg Close $119.81 Range $103.75 - $136.33

Q3 2013

Shares 830,268 Value ($000) $62,951 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 759,400 Value ($000) $60,653,278 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2025	650,259	$289,495	$460.83	$416.60 - $510.77
Q1 2025	719,131	$348,649	$466.00	$397.25 - $519.68
Q4 2024	664,523	$267,603	$463.53	$377.85 - $519.88
Q3 2024	550,273	$255,921	$480.37	$456.07 - $510.64
Q2 2024	515,386	$241,572	$434.05	$391.01 - $486.43
Q1 2024	552,882	$231,110	$422.74	$403.43 - $448.40
Q4 2023	576,507	$234,575	$369.42	$341.85 - $413.00
Q3 2023	585,841	$203,720	$349.73	$335.82 - $367.00
Q2 2023	639,796	$225,151	$336.94	$313.47 - $354.94
Q1 2023	641,555	$202,135	$299.93	$282.21 - $325.19
Q4 2022	188,470	$54,426	$304.77	$283.58 - $324.75
Q3 2022	227,704	$65,929	$287.72	$271.61 - $305.95
Q2 2022	378,580	$106,680	$267.66	$233.01 - $293.17
Q1 2022	474,393	$123,802	$237.33	$214.66 - $263.58
Q4 2021	462,314	$101,524	$194.45	$176.36 - $224.49
Q3 2021	465,031	$84,352	$195.24	$180.02 - $204.88
Q2 2021	466,109	$93,982	$209.17	$185.33 - $222.78
Q3 2020	45,582	$12,404	$275.88	$253.97 - $306.08
Q3 2015	60,637	$6,315	$128.47	$97.45 - $143.45
Q2 2015	58,748	$7,254	$125.98	$113.68 - $137.50
Q1 2015	59,052	$6,966	$119.81	$103.75 - $136.33
Q3 2013	830,268	$62,951	$79.58	$73.43 - $89.96
Q2 2013	759,400	$60,653,278	$73.64	$51.28 - $87.47