VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Mitsubishi UFJ Kokusai Asset Management Co., Ltd.'s Holding History (CIK: 0001466546)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 566,227 Value ($000) $256,008 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 544,978 Value ($000) $213,435 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 524,925 Value ($000) $233,697 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 489,067 Value ($000) $237,109 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 438,091 Value ($000) $178,351 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 405,352 Value ($000) $188,521 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 371,481 Value ($000) $174,121 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 333,142 Value ($000) $139,257 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 275,415 Value ($000) $113,116 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 254,083 Value ($000) $88,355 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 232,826 Value ($000) $81,934 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 218,117 Value ($000) $68,722 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 196,887 Value ($000) $56,314 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 177,989 Value ($000) $51,535 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 161,398 Value ($000) $45,480 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 148,247 Value ($000) $38,688 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 136,168 Value ($000) $30,301 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 116,439 Value ($000) $21,121 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 105,091 Value ($000) $21,189 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 102,297 Value ($000) $21,983 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 90,505 Value ($000) $21,390 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 82,389 Value ($000) $22,420 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 64,472 Value ($000) $18,717 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 52,128 Value ($000) $12,404 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 51,078 Value ($000) $11,134 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 44,555 Value ($000) $7,549 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 42,730 Value ($000) $7,836 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 34,276 Value ($000) $6,305 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 32,194 Value ($000) $5,271 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 34,658 Value ($000) $6,680 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 35,730 Value ($000) $6,073 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 35,678 Value ($000) $5,815 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 39,111 Value ($000) $5,945 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 37,533 Value ($000) $5,707 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 36,425 Value ($000) $4,694 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 40,598 Value ($000) $4,439 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 39,163 Value ($000) $2,933 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 38,183 Value ($000) $3,330 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 36,859 Value ($000) $3,171 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 35,709 Value ($000) $2,839 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 32,494 Value ($000) $4,089 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 30,567 Value ($000) $3,183 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 30,522 Value ($000) $3,769 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 32,329 Value ($000) $3,814 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 33,820 Value ($000) $4,162 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 38,045 Value ($000) $4,273 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 45,924 Value ($000) $4,348 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 45,675 Value ($000) $3,230 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 43,139 Value ($000) $3,169 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 51,301 Value ($000) $3,890 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 47,500 Value ($000) $3,794 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	566,227	$256,008	$431.03	$392.50 - $464.44
Q3 2025	544,978	$213,435	$417.92	$362.50 - $484.56
Q2 2025	524,925	$233,697	$460.83	$416.60 - $510.77
Q1 2025	489,067	$237,109	$466.00	$397.25 - $519.68
Q4 2024	438,091	$178,351	$463.53	$377.85 - $519.88
Q3 2024	405,352	$188,521	$480.37	$456.07 - $510.64
Q2 2024	371,481	$174,121	$434.05	$391.01 - $486.43
Q1 2024	333,142	$139,257	$422.74	$403.43 - $448.40
Q4 2023	275,415	$113,116	$369.42	$341.85 - $413.00
Q3 2023	254,083	$88,355	$349.73	$335.82 - $367.00
Q2 2023	232,826	$81,934	$336.94	$313.47 - $354.94
Q1 2023	218,117	$68,722	$299.93	$282.21 - $325.19
Q4 2022	196,887	$56,314	$304.77	$283.58 - $324.75
Q3 2022	177,989	$51,535	$287.72	$271.61 - $305.95
Q2 2022	161,398	$45,480	$267.66	$233.01 - $293.17
Q1 2022	148,247	$38,688	$237.33	$214.66 - $263.58
Q4 2021	136,168	$30,301	$194.45	$176.36 - $224.49
Q3 2021	116,439	$21,121	$195.24	$180.02 - $204.88
Q2 2021	105,091	$21,189	$209.17	$185.33 - $222.78
Q1 2021	102,297	$21,983	$219.65	$204.62 - $242.99
Q4 2020	90,505	$21,390	$229.44	$202.57 - $280.99
Q3 2020	82,389	$22,420	$275.88	$253.97 - $306.08
Q2 2020	64,472	$18,717	$271.12	$222.39 - $299.21
Q1 2020	52,128	$12,404	$229.39	$197.47 - $249.85
Q4 2019	51,078	$11,134	$202.38	$165.23 - $225.66
Q3 2019	44,555	$7,549	$176.91	$165.27 - $188.44
Q2 2019	42,730	$7,836	$174.82	$163.68 - $191.71
Q1 2019	34,276	$6,305	$184.70	$160.95 - $195.81
Q4 2018	32,194	$5,271	$173.27	$151.80 - $194.92
Q3 2018	34,658	$6,680	$178.07	$164.70 - $193.78
Q2 2018	35,730	$6,073	$155.01	$144.07 - $172.00
Q1 2018	35,678	$5,815	$163.34	$146.21 - $178.15
Q4 2017	39,111	$5,945	$148.07	$136.50 - $158.04
Q3 2017	37,533	$5,707	$150.51	$125.50 - $167.86
Q2 2017	36,425	$4,694	$120.38	$107.24 - $137.26
Q1 2017	40,598	$4,439	$88.04	$73.34 - $111.88
Q4 2016	39,163	$2,933	$81.37	$71.46 - $97.93
Q3 2016	38,183	$3,330	$94.50	$83.50 - $103.73
Q2 2016	36,859	$3,171	$86.41	$75.92 - $96.49
Q1 2016	35,709	$2,839	$90.45	$75.90 - $124.96
Q4 2015	32,494	$4,089	$120.72	$101.49 - $134.71
Q3 2015	30,567	$3,183	$128.47	$97.45 - $143.45
Q2 2015	30,522	$3,769	$125.98	$113.68 - $137.50
Q1 2015	32,329	$3,814	$119.81	$103.75 - $136.33
Q4 2014	33,820	$4,162	$112.63	$96.43 - $124.35
Q3 2014	38,045	$4,273	$95.21	$84.41 - $116.88
Q2 2014	45,924	$4,348	$70.12	$59.79 - $98.80
Q1 2014	45,675	$3,230	$79.20	$67.49 - $87.77
Q4 2013	43,139	$3,169	$69.64	$58.06 - $78.38
Q3 2013	51,301	$3,890	$79.58	$73.43 - $89.96
Q2 2013	47,500	$3,794	$73.64	$51.28 - $87.47