VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025
Shares 98,360 Value ($000) $44,592 Avg Close $431.03 Range $392.50 - $464.44
Q3 2025
Shares 11,500 Value ($000) $4,504 Avg Close $417.92 Range $362.50 - $484.56
Q2 2025
Shares 900 Value ($000) $401 Avg Close $460.83 Range $416.60 - $510.77
Q4 2024
Shares 3,200 Value ($000) $1,289 Avg Close $463.53 Range $377.85 - $519.88
Q3 2024
Shares 29,400 Value ($000) $13,673 Avg Close $480.37 Range $456.07 - $510.64
Q2 2024
Shares 171,800 Value ($000) $80,526 Avg Close $434.05 Range $391.01 - $486.43
Q1 2024
Shares 122,000 Value ($000) $50,997 Avg Close $422.74 Range $403.43 - $448.40
Q4 2023
Shares 87,500 Value ($000) $35,603 Avg Close $369.42 Range $341.85 - $413.00
Q3 2023
Shares 143,400 Value ($000) $49,866 Avg Close $349.73 Range $335.82 - $367.00
Q2 2023
Shares 214,400 Value ($000) $75,450 Avg Close $336.94 Range $313.47 - $354.94
Q1 2023
Shares 60,400 Value ($000) $19,030 Avg Close $299.93 Range $282.21 - $325.19
Q4 2022
Shares 17,800 Value ($000) $5,140 Avg Close $304.77 Range $283.58 - $324.75
Q3 2022
Shares 23,000 Value ($000) $6,659 Avg Close $287.72 Range $271.61 - $305.95
Q2 2022
Shares 24,700 Value ($000) $6,960 Avg Close $267.66 Range $233.01 - $293.17
Q1 2022
Shares 17,800 Value ($000) $4,645 Avg Close $237.33 Range $214.66 - $263.58
Q4 2021
Shares 12,300 Value ($000) $2,701 Avg Close $194.45 Range $176.36 - $224.49
Q3 2021
Shares 782,700 Value ($000) $141,974 Avg Close $195.24 Range $180.02 - $204.88
Q2 2021
Shares 1,000 Value ($000) $202 Avg Close $209.17 Range $185.33 - $222.78
Q4 2020
Shares 262,837 Value ($000) $62,119 Avg Close $229.44 Range $202.57 - $280.99
Q3 2020
Shares 777,637 Value ($000) $211,611 Avg Close $275.88 Range $253.97 - $306.08
Q2 2020
Shares 1,215,912 Value ($000) $352,991 Avg Close $271.12 Range $222.39 - $299.21
Q1 2020
Shares 1,102,012 Value ($000) $262,224 Avg Close $229.39 Range $197.47 - $249.85
Q4 2019
Shares 1,204,712 Value ($000) $263,772 Avg Close $202.38 Range $165.23 - $225.66
Q3 2019
Shares 903,612 Value ($000) $153,090 Avg Close $176.91 Range $165.27 - $188.44
Q2 2019
Shares 935,712 Value ($000) $171,591 Avg Close $174.82 Range $163.68 - $191.71
Q1 2019
Shares 1,003,412 Value ($000) $184,578 Avg Close $184.70 Range $160.95 - $195.81
Q4 2018
Shares 745,012 Value ($000) $123,456 Avg Close $173.27 Range $151.80 - $194.92
Q3 2018
Shares 526,012 Value ($000) $101,384 Avg Close $178.07 Range $164.70 - $193.78
Q2 2018
Shares 333,412 Value ($000) $56,667 Avg Close $155.01 Range $144.07 - $172.00
Q1 2018
Shares 813,212 Value ($000) $132,537 Avg Close $163.34 Range $146.21 - $178.15
Q4 2017
Shares 1,227,412 Value ($000) $183,940 Avg Close $148.07 Range $136.50 - $158.04
Q3 2017
Shares 859,250 Value ($000) $130,640 Avg Close $150.51 Range $125.50 - $167.86
Q2 2017
Shares 862,601 Value ($000) $111,163 Avg Close $120.38 Range $107.24 - $137.26
Q1 2017
Shares 1,158,368 Value ($000) $126,668 Avg Close $88.04 Range $73.34 - $111.88
Q4 2016
Shares 1,094,829 Value ($000) $80,656 Avg Close $81.37 Range $71.46 - $97.93
Q3 2016
Shares 260,353 Value ($000) $22,705 Avg Close $94.50 Range $83.50 - $103.73
Q2 2016
Shares 232,286 Value ($000) $19,981 Avg Close $86.41 Range $75.92 - $96.49
Q1 2016
Shares 945,666 Value ($000) $75,171 Avg Close $90.45 Range $75.90 - $124.96
Q4 2015
Shares 272,690 Value ($000) $34,313 Avg Close $120.72 Range $101.49 - $134.71
Q3 2015
Shares 301,296 Value ($000) $32,050 Avg Close $128.47 Range $97.45 - $143.45
Q2 2015
Shares 13,496 Value ($000) $1,666 Avg Close $125.98 Range $113.68 - $137.50