VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Meiji Yasuda Asset Management Co Ltd.'s Holding History (CIK: 0001491685)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 9,221 Value ($000) $4,180 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 9,500 Value ($000) $3,721 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 9,633 Value ($000) $4,289 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 12,646 Value ($000) $6,131 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 13,263 Value ($000) $5,341 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 13,070 Value ($000) $6,079 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 12,910 Value ($000) $6,051 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 5,878 Value ($000) $2,457 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 9,259 Value ($000) $3,767 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 8,315 Value ($000) $2,891 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 5,269 Value ($000) $2 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 5,334 Value ($000) $2 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 9,050 Value ($000) $3 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 19,890 Value ($000) $5,759 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 20,271 Value ($000) $5,712 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 22,122 Value ($000) $5,773 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 23,206 Value ($000) $5,096 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 22,935 Value ($000) $4,160 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 22,525 Value ($000) $4,542 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 22,727 Value ($000) $4,884 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 21,573 Value ($000) $5,099 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 15,923 Value ($000) $4,333 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 17,923 Value ($000) $5,203 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 4,814 Value ($000) $1,145 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 6,534 Value ($000) $1,431 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 8,984 Value ($000) $1,522 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 7,959 Value ($000) $1,460 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 7,179 Value ($000) $1,321 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 5,629 Value ($000) $933 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 5,719 Value ($000) $1,102 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 5,129 Value ($000) $872 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 6,509 Value ($000) $1,061 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 3,709 Value ($000) $556 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 3,709 Value ($000) $564 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 5,409 Value ($000) $697 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 3,209 Value ($000) $351 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 3,209 Value ($000) $236 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 3,209 Value ($000) $280 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 2,339 Value ($000) $201 Avg Close $86.41 Range $75.92 - $96.49

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	9,221	$4,180	$431.03	$392.50 - $464.44
Q3 2025	9,500	$3,721	$417.92	$362.50 - $484.56
Q2 2025	9,633	$4,289	$460.83	$416.60 - $510.77
Q1 2025	12,646	$6,131	$466.00	$397.25 - $519.68
Q4 2024	13,263	$5,341	$463.53	$377.85 - $519.88
Q3 2024	13,070	$6,079	$480.37	$456.07 - $510.64
Q2 2024	12,910	$6,051	$434.05	$391.01 - $486.43
Q1 2024	5,878	$2,457	$422.74	$403.43 - $448.40
Q4 2023	9,259	$3,767	$369.42	$341.85 - $413.00
Q3 2023	8,315	$2,891	$349.73	$335.82 - $367.00
Q2 2023	5,269	$2	$336.94	$313.47 - $354.94
Q1 2023	5,334	$2	$299.93	$282.21 - $325.19
Q4 2022	9,050	$3	$304.77	$283.58 - $324.75
Q3 2022	19,890	$5,759	$287.72	$271.61 - $305.95
Q2 2022	20,271	$5,712	$267.66	$233.01 - $293.17
Q1 2022	22,122	$5,773	$237.33	$214.66 - $263.58
Q4 2021	23,206	$5,096	$194.45	$176.36 - $224.49
Q3 2021	22,935	$4,160	$195.24	$180.02 - $204.88
Q2 2021	22,525	$4,542	$209.17	$185.33 - $222.78
Q1 2021	22,727	$4,884	$219.65	$204.62 - $242.99
Q4 2020	21,573	$5,099	$229.44	$202.57 - $280.99
Q3 2020	15,923	$4,333	$275.88	$253.97 - $306.08
Q2 2020	17,923	$5,203	$271.12	$222.39 - $299.21
Q1 2020	4,814	$1,145	$229.39	$197.47 - $249.85
Q4 2019	6,534	$1,431	$202.38	$165.23 - $225.66
Q3 2019	8,984	$1,522	$176.91	$165.27 - $188.44
Q2 2019	7,959	$1,460	$174.82	$163.68 - $191.71
Q1 2019	7,179	$1,321	$184.70	$160.95 - $195.81
Q4 2018	5,629	$933	$173.27	$151.80 - $194.92
Q3 2018	5,719	$1,102	$178.07	$164.70 - $193.78
Q2 2018	5,129	$872	$155.01	$144.07 - $172.00
Q1 2018	6,509	$1,061	$163.34	$146.21 - $178.15
Q4 2017	3,709	$556	$148.07	$136.50 - $158.04
Q3 2017	3,709	$564	$150.51	$125.50 - $167.86
Q2 2017	5,409	$697	$120.38	$107.24 - $137.26
Q1 2017	3,209	$351	$88.04	$73.34 - $111.88
Q4 2016	3,209	$236	$81.37	$71.46 - $97.93
Q3 2016	3,209	$280	$94.50	$83.50 - $103.73
Q2 2016	2,339	$201	$86.41	$75.92 - $96.49