VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Norinchukin Bank, The's Holding History (CIK: 0001496637)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 24,203 Value ($000) $10,973 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 22,026 Value ($000) $8,626 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 21,936 Value ($000) $9,766 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 20,077 Value ($000) $9,734 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 13,957 Value ($000) $5,620 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 12,851 Value ($000) $5,977 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 11,135 Value ($000) $5,219 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 11,130 Value ($000) $4,652 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 11,367 Value ($000) $4,625 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 13,026 Value ($000) $4,530 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 26,829 Value ($000) $9,441 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 20,207 Value ($000) $6,367 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 19,685 Value ($000) $5,685 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 24,076 Value ($000) $6,971 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 21,638 Value ($000) $6,097 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 26,357 Value ($000) $6,878 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 23,875 Value ($000) $5,243 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 25,794 Value ($000) $4,679 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 24,395 Value ($000) $4,919 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 24,178 Value ($000) $5,196 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 23,043 Value ($000) $5,446 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 23,175 Value ($000) $6,306 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 22,397 Value ($000) $6,502 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 22,388 Value ($000) $5,327 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 34,809 Value ($000) $7,621 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 37,817 Value ($000) $6,407 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 36,813 Value ($000) $6,751 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 49,255 Value ($000) $9,060 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 47,529 Value ($000) $7,876 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 32,871 Value ($000) $6,336 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 28,873 Value ($000) $4,907 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 23,265 Value ($000) $3,792 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 20,219 Value ($000) $3,030 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 18,765 Value ($000) $2,853 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 17,284 Value ($000) $2,227 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 16,144 Value ($000) $1,765 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 15,047 Value ($000) $1,109 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 13,266 Value ($000) $1,157 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 12,974 Value ($000) $1,116 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 12,645 Value ($000) $1,005 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 11,479 Value ($000) $1,444 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 13,995 Value ($000) $1,457 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 13,800 Value ($000) $1,704 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 14,353 Value ($000) $1,693 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 14,173 Value ($000) $1,684 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 9,559 Value ($000) $1,074 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 8,813 Value ($000) $834 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 9,756 Value ($000) $690 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 8,732 Value ($000) $649 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 8,744 Value ($000) $663 Avg Close $79.58 Range $73.43 - $89.96

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	24,203	$10,973	$431.03	$392.50 - $464.44
Q3 2025	22,026	$8,626	$417.92	$362.50 - $484.56
Q2 2025	21,936	$9,766	$460.83	$416.60 - $510.77
Q1 2025	20,077	$9,734	$466.00	$397.25 - $519.68
Q4 2024	13,957	$5,620	$463.53	$377.85 - $519.88
Q3 2024	12,851	$5,977	$480.37	$456.07 - $510.64
Q2 2024	11,135	$5,219	$434.05	$391.01 - $486.43
Q1 2024	11,130	$4,652	$422.74	$403.43 - $448.40
Q4 2023	11,367	$4,625	$369.42	$341.85 - $413.00
Q3 2023	13,026	$4,530	$349.73	$335.82 - $367.00
Q2 2023	26,829	$9,441	$336.94	$313.47 - $354.94
Q1 2023	20,207	$6,367	$299.93	$282.21 - $325.19
Q4 2022	19,685	$5,685	$304.77	$283.58 - $324.75
Q3 2022	24,076	$6,971	$287.72	$271.61 - $305.95
Q2 2022	21,638	$6,097	$267.66	$233.01 - $293.17
Q1 2022	26,357	$6,878	$237.33	$214.66 - $263.58
Q4 2021	23,875	$5,243	$194.45	$176.36 - $224.49
Q3 2021	25,794	$4,679	$195.24	$180.02 - $204.88
Q2 2021	24,395	$4,919	$209.17	$185.33 - $222.78
Q1 2021	24,178	$5,196	$219.65	$204.62 - $242.99
Q4 2020	23,043	$5,446	$229.44	$202.57 - $280.99
Q3 2020	23,175	$6,306	$275.88	$253.97 - $306.08
Q2 2020	22,397	$6,502	$271.12	$222.39 - $299.21
Q1 2020	22,388	$5,327	$229.39	$197.47 - $249.85
Q4 2019	34,809	$7,621	$202.38	$165.23 - $225.66
Q3 2019	37,817	$6,407	$176.91	$165.27 - $188.44
Q2 2019	36,813	$6,751	$174.82	$163.68 - $191.71
Q1 2019	49,255	$9,060	$184.70	$160.95 - $195.81
Q4 2018	47,529	$7,876	$173.27	$151.80 - $194.92
Q3 2018	32,871	$6,336	$178.07	$164.70 - $193.78
Q2 2018	28,873	$4,907	$155.01	$144.07 - $172.00
Q1 2018	23,265	$3,792	$163.34	$146.21 - $178.15
Q4 2017	20,219	$3,030	$148.07	$136.50 - $158.04
Q3 2017	18,765	$2,853	$150.51	$125.50 - $167.86
Q2 2017	17,284	$2,227	$120.38	$107.24 - $137.26
Q1 2017	16,144	$1,765	$88.04	$73.34 - $111.88
Q4 2016	15,047	$1,109	$81.37	$71.46 - $97.93
Q3 2016	13,266	$1,157	$94.50	$83.50 - $103.73
Q2 2016	12,974	$1,116	$86.41	$75.92 - $96.49
Q1 2016	12,645	$1,005	$90.45	$75.90 - $124.96
Q4 2015	11,479	$1,444	$120.72	$101.49 - $134.71
Q3 2015	13,995	$1,457	$128.47	$97.45 - $143.45
Q2 2015	13,800	$1,704	$125.98	$113.68 - $137.50
Q1 2015	14,353	$1,693	$119.81	$103.75 - $136.33
Q4 2014	14,173	$1,684	$112.63	$96.43 - $124.35
Q3 2014	9,559	$1,074	$95.21	$84.41 - $116.88
Q2 2014	8,813	$834	$70.12	$59.79 - $98.80
Q1 2014	9,756	$690	$79.20	$67.49 - $87.77
Q4 2013	8,732	$649	$69.64	$58.06 - $78.38
Q3 2013	8,744	$663	$79.58	$73.43 - $89.96