VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Brevan Howard Capital Management LP's Holding History (CIK: 0001512857)

Note: Option positions (PUT/CALL) are excluded.

Q4 2024

Shares 7,270 Value ($000) $2,928 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 7,389 Value ($000) $3,436 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 4,424 Value ($000) $2,074 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 4,632 Value ($000) $1,936 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 4,830 Value ($000) $1,965 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 1,527 Value ($000) $531 Avg Close $349.73 Range $335.82 - $367.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2024	7,270	$2,928	$463.53	$377.85 - $519.88
Q3 2024	7,389	$3,436	$480.37	$456.07 - $510.64
Q2 2024	4,424	$2,074	$434.05	$391.01 - $486.43
Q1 2024	4,632	$1,936	$422.74	$403.43 - $448.40
Q4 2023	4,830	$1,965	$369.42	$341.85 - $413.00
Q3 2023	1,527	$531	$349.73	$335.82 - $367.00