VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Tower Research Capital LLC (TRC)'s Holding History (CIK: 0001533421)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 13,579 Value ($000) $6,156 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 14,022 Value ($000) $5,492 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 23,478 Value ($000) $10,452 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 13,116 Value ($000) $6,328 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 20,680 Value ($000) $8,328 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 7,164 Value ($000) $3,332 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 36,303 Value ($000) $17,016 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 17,773 Value ($000) $7,429 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 45,581 Value ($000) $18,546 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 15,406 Value ($000) $5,357 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 9,679 Value ($000) $3,406 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 6,844 Value ($000) $2 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 9,573 Value ($000) $3 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 60,813 Value ($000) $17,608 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 46,861 Value ($000) $13,205 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 77,497 Value ($000) $20,224 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 29,743 Value ($000) $6,532 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 25,871 Value ($000) $4,693 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 9,503 Value ($000) $1,916 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 31,434 Value ($000) $6,755 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 6,652 Value ($000) $1,572 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 13,996 Value ($000) $3,809 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 5,608 Value ($000) $1,628 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 113 Value ($000) $27 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 897 Value ($000) $196 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 5,633 Value ($000) $955 Avg Close $176.91 Range $165.27 - $188.44

Q1 2019

Shares 6,247 Value ($000) $1,149 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 925 Value ($000) $153 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 1,715 Value ($000) $331 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 12,634 Value ($000) $2,147 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 166 Value ($000) $27 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 537 Value ($000) $81 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 2,389 Value ($000) $363 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 142 Value ($000) $18 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 1 Value ($000) $0 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 6,723 Value ($000) $495 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 3,717 Value ($000) $324 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 538 Value ($000) $46 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 1,547 Value ($000) $123 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 322 Value ($000) $41 Avg Close $120.72 Range $101.49 - $134.71

Q2 2015

Shares 703 Value ($000) $87 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 6,776 Value ($000) $799 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 460 Value ($000) $55 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 644 Value ($000) $72 Avg Close $95.21 Range $84.41 - $116.88

Q4 2013

Shares 6,473 Value ($000) $481 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 10,047 Value ($000) $761 Avg Close $79.58 Range $73.43 - $89.96

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	13,579	$6,156	$431.03	$392.50 - $464.44
Q3 2025	14,022	$5,492	$417.92	$362.50 - $484.56
Q2 2025	23,478	$10,452	$460.83	$416.60 - $510.77
Q1 2025	13,116	$6,328	$466.00	$397.25 - $519.68
Q4 2024	20,680	$8,328	$463.53	$377.85 - $519.88
Q3 2024	7,164	$3,332	$480.37	$456.07 - $510.64
Q2 2024	36,303	$17,016	$434.05	$391.01 - $486.43
Q1 2024	17,773	$7,429	$422.74	$403.43 - $448.40
Q4 2023	45,581	$18,546	$369.42	$341.85 - $413.00
Q3 2023	15,406	$5,357	$349.73	$335.82 - $367.00
Q2 2023	9,679	$3,406	$336.94	$313.47 - $354.94
Q1 2023	6,844	$2	$299.93	$282.21 - $325.19
Q4 2022	9,573	$3	$304.77	$283.58 - $324.75
Q3 2022	60,813	$17,608	$287.72	$271.61 - $305.95
Q2 2022	46,861	$13,205	$267.66	$233.01 - $293.17
Q1 2022	77,497	$20,224	$237.33	$214.66 - $263.58
Q4 2021	29,743	$6,532	$194.45	$176.36 - $224.49
Q3 2021	25,871	$4,693	$195.24	$180.02 - $204.88
Q2 2021	9,503	$1,916	$209.17	$185.33 - $222.78
Q1 2021	31,434	$6,755	$219.65	$204.62 - $242.99
Q4 2020	6,652	$1,572	$229.44	$202.57 - $280.99
Q3 2020	13,996	$3,809	$275.88	$253.97 - $306.08
Q2 2020	5,608	$1,628	$271.12	$222.39 - $299.21
Q1 2020	113	$27	$229.39	$197.47 - $249.85
Q4 2019	897	$196	$202.38	$165.23 - $225.66
Q3 2019	5,633	$955	$176.91	$165.27 - $188.44
Q1 2019	6,247	$1,149	$184.70	$160.95 - $195.81
Q4 2018	925	$153	$173.27	$151.80 - $194.92
Q3 2018	1,715	$331	$178.07	$164.70 - $193.78
Q2 2018	12,634	$2,147	$155.01	$144.07 - $172.00
Q1 2018	166	$27	$163.34	$146.21 - $178.15
Q4 2017	537	$81	$148.07	$136.50 - $158.04
Q3 2017	2,389	$363	$150.51	$125.50 - $167.86
Q2 2017	142	$18	$120.38	$107.24 - $137.26
Q1 2017	1	$0	$88.04	$73.34 - $111.88
Q4 2016	6,723	$495	$81.37	$71.46 - $97.93
Q3 2016	3,717	$324	$94.50	$83.50 - $103.73
Q2 2016	538	$46	$86.41	$75.92 - $96.49
Q1 2016	1,547	$123	$90.45	$75.90 - $124.96
Q4 2015	322	$41	$120.72	$101.49 - $134.71
Q2 2015	703	$87	$125.98	$113.68 - $137.50
Q1 2015	6,776	$799	$119.81	$103.75 - $136.33
Q4 2014	460	$55	$112.63	$96.43 - $124.35
Q3 2014	644	$72	$95.21	$84.41 - $116.88
Q4 2013	6,473	$481	$69.64	$58.06 - $78.38
Q3 2013	10,047	$761	$79.58	$73.43 - $89.96