VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND's Holding History (CIK: 0001535845)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 87,728 Value ($000) $39,772 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 83,846 Value ($000) $32,837 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 98,561 Value ($000) $43,879 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 149,540 Value ($000) $72,500 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 72,209 Value ($000) $29,079 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 49,065 Value ($000) $22,819 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 23,690 Value ($000) $11,104 Avg Close $434.05 Range $391.01 - $486.43

Q4 2023

Shares 46,000 Value ($000) $18,717 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 73,000 Value ($000) $25,385 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 13,300 Value ($000) $4,680 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 394 Value ($000) $124 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 293 Value ($000) $85 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 5,370 Value ($000) $1,555 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 34,374 Value ($000) $9,686 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 21,284 Value ($000) $5,554 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 85,144 Value ($000) $18,698 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 129,160 Value ($000) $23,428 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 187,894 Value ($000) $37,885 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 253 Value ($000) $54 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 85,198 Value ($000) $20,136 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 33 Value ($000) $9 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 33 Value ($000) $10 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 118 Value ($000) $28 Avg Close $229.39 Range $197.47 - $249.85

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	87,728	$39,772	$431.03	$392.50 - $464.44
Q3 2025	83,846	$32,837	$417.92	$362.50 - $484.56
Q2 2025	98,561	$43,879	$460.83	$416.60 - $510.77
Q1 2025	149,540	$72,500	$466.00	$397.25 - $519.68
Q4 2024	72,209	$29,079	$463.53	$377.85 - $519.88
Q3 2024	49,065	$22,819	$480.37	$456.07 - $510.64
Q2 2024	23,690	$11,104	$434.05	$391.01 - $486.43
Q4 2023	46,000	$18,717	$369.42	$341.85 - $413.00
Q3 2023	73,000	$25,385	$349.73	$335.82 - $367.00
Q2 2023	13,300	$4,680	$336.94	$313.47 - $354.94
Q1 2023	394	$124	$299.93	$282.21 - $325.19
Q4 2022	293	$85	$304.77	$283.58 - $324.75
Q3 2022	5,370	$1,555	$287.72	$271.61 - $305.95
Q2 2022	34,374	$9,686	$267.66	$233.01 - $293.17
Q1 2022	21,284	$5,554	$237.33	$214.66 - $263.58
Q4 2021	85,144	$18,698	$194.45	$176.36 - $224.49
Q3 2021	129,160	$23,428	$195.24	$180.02 - $204.88
Q2 2021	187,894	$37,885	$209.17	$185.33 - $222.78
Q1 2021	253	$54	$219.65	$204.62 - $242.99
Q4 2020	85,198	$20,136	$229.44	$202.57 - $280.99
Q3 2020	33	$9	$275.88	$253.97 - $306.08
Q2 2020	33	$10	$271.12	$222.39 - $299.21
Q1 2020	118	$28	$229.39	$197.47 - $249.85