VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Horizon Investments, LLC's Holding History (CIK: 0001560717)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 11,375 Value ($000) $5,157 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 9,194 Value ($000) $3,601 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 7,842 Value ($000) $3,491 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 5,049 Value ($000) $2,448 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 4,969 Value ($000) $2,001 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 4,883 Value ($000) $2,271 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 4,938 Value ($000) $2,315 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 5,072 Value ($000) $2,120 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 4,890 Value ($000) $1,990 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 4,487 Value ($000) $1,560 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 4,431 Value ($000) $1,559 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 4,627 Value ($000) $1,458 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 7,263 Value ($000) $2 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 10,901 Value ($000) $3,156 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 3,453 Value ($000) $973 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 11,370 Value ($000) $2,967 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 9,466 Value ($000) $2,079 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 2,741 Value ($000) $497 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 3,580 Value ($000) $722 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 2,452 Value ($000) $527 Avg Close $219.65 Range $204.62 - $242.99

Q3 2020

Shares 7,238 Value ($000) $1,970 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 4,858 Value ($000) $1,410 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 3,218 Value ($000) $766 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 2,825 Value ($000) $619 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 1,592 Value ($000) $270 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 1,679 Value ($000) $308 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 1,331 Value ($000) $245 Avg Close $184.70 Range $160.95 - $195.81

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	11,375	$5,157	$431.03	$392.50 - $464.44
Q3 2025	9,194	$3,601	$417.92	$362.50 - $484.56
Q2 2025	7,842	$3,491	$460.83	$416.60 - $510.77
Q1 2025	5,049	$2,448	$466.00	$397.25 - $519.68
Q4 2024	4,969	$2,001	$463.53	$377.85 - $519.88
Q3 2024	4,883	$2,271	$480.37	$456.07 - $510.64
Q2 2024	4,938	$2,315	$434.05	$391.01 - $486.43
Q1 2024	5,072	$2,120	$422.74	$403.43 - $448.40
Q4 2023	4,890	$1,990	$369.42	$341.85 - $413.00
Q3 2023	4,487	$1,560	$349.73	$335.82 - $367.00
Q2 2023	4,431	$1,559	$336.94	$313.47 - $354.94
Q1 2023	4,627	$1,458	$299.93	$282.21 - $325.19
Q4 2022	7,263	$2	$304.77	$283.58 - $324.75
Q3 2022	10,901	$3,156	$287.72	$271.61 - $305.95
Q2 2022	3,453	$973	$267.66	$233.01 - $293.17
Q1 2022	11,370	$2,967	$237.33	$214.66 - $263.58
Q4 2021	9,466	$2,079	$194.45	$176.36 - $224.49
Q3 2021	2,741	$497	$195.24	$180.02 - $204.88
Q2 2021	3,580	$722	$209.17	$185.33 - $222.78
Q1 2021	2,452	$527	$219.65	$204.62 - $242.99
Q3 2020	7,238	$1,970	$275.88	$253.97 - $306.08
Q2 2020	4,858	$1,410	$271.12	$222.39 - $299.21
Q1 2020	3,218	$766	$229.39	$197.47 - $249.85
Q4 2019	2,825	$619	$202.38	$165.23 - $225.66
Q3 2019	1,592	$270	$176.91	$165.27 - $188.44
Q2 2019	1,679	$308	$174.82	$163.68 - $191.71
Q1 2019	1,331	$245	$184.70	$160.95 - $195.81