VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Capital International Investors's Holding History (CIK: 0001562230)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 4,733,596 Value ($000) $2,146,041 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 4,689,059 Value ($000) $1,836,550 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 2,635,903 Value ($000) $1,173,392 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 649,899 Value ($000) $315,084 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 342,512 Value ($000) $137,930 Avg Close $463.53 Range $377.85 - $519.88

Q1 2022

Shares 125,595 Value ($000) $32,777 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 2,027,232 Value ($000) $445,192 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 3,949,552 Value ($000) $716,412 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 4,549,003 Value ($000) $917,201 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 6,042,569 Value ($000) $1,298,481 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 6,685,422 Value ($000) $1,580,021 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 5,486,084 Value ($000) $1,492,833 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 5,747,509 Value ($000) $1,668,456 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 6,542,598 Value ($000) $1,556,807 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 6,264,794 Value ($000) $1,371,677 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 3,023,390 Value ($000) $512,223 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 3,023,267 Value ($000) $554,407 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 3,090,171 Value ($000) $568,437 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 2,697,523 Value ($000) $447,007 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 2,871,923 Value ($000) $553,534 Avg Close $178.07 Range $164.70 - $193.78

Q2 2015

Shares 111 Value ($000) $14 Avg Close $125.98 Range $113.68 - $137.50

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	4,733,596	$2,146,041	$431.03	$392.50 - $464.44
Q3 2025	4,689,059	$1,836,550	$417.92	$362.50 - $484.56
Q2 2025	2,635,903	$1,173,392	$460.83	$416.60 - $510.77
Q1 2025	649,899	$315,084	$466.00	$397.25 - $519.68
Q4 2024	342,512	$137,930	$463.53	$377.85 - $519.88
Q1 2022	125,595	$32,777	$237.33	$214.66 - $263.58
Q4 2021	2,027,232	$445,192	$194.45	$176.36 - $224.49
Q3 2021	3,949,552	$716,412	$195.24	$180.02 - $204.88
Q2 2021	4,549,003	$917,201	$209.17	$185.33 - $222.78
Q1 2021	6,042,569	$1,298,481	$219.65	$204.62 - $242.99
Q4 2020	6,685,422	$1,580,021	$229.44	$202.57 - $280.99
Q3 2020	5,486,084	$1,492,833	$275.88	$253.97 - $306.08
Q2 2020	5,747,509	$1,668,456	$271.12	$222.39 - $299.21
Q1 2020	6,542,598	$1,556,807	$229.39	$197.47 - $249.85
Q4 2019	6,264,794	$1,371,677	$202.38	$165.23 - $225.66
Q3 2019	3,023,390	$512,223	$176.91	$165.27 - $188.44
Q2 2019	3,023,267	$554,407	$174.82	$163.68 - $191.71
Q1 2019	3,090,171	$568,437	$184.70	$160.95 - $195.81
Q4 2018	2,697,523	$447,007	$173.27	$151.80 - $194.92
Q3 2018	2,871,923	$553,534	$178.07	$164.70 - $193.78
Q2 2015	111	$14	$125.98	$113.68 - $137.50