VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Carmignac Gestion's Holding History (CIK: 0001569758)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 191,571 Value ($000) $86,854 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 187,539 Value ($000) $73,460 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 227,296 Value ($000) $101,156 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 126,954 Value ($000) $61,612 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 197,466 Value ($000) $79,491 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 210,522 Value ($000) $97,894 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 185,249 Value ($000) $86,850 Avg Close $434.05 Range $391.01 - $486.43

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	191,571	$86,854	$431.03	$392.50 - $464.44
Q3 2025	187,539	$73,460	$417.92	$362.50 - $484.56
Q2 2025	227,296	$101,156	$460.83	$416.60 - $510.77
Q1 2025	126,954	$61,612	$466.00	$397.25 - $519.68
Q4 2024	197,466	$79,491	$463.53	$377.85 - $519.88
Q3 2024	210,522	$97,894	$480.37	$456.07 - $510.64
Q2 2024	185,249	$86,850	$434.05	$391.01 - $486.43