VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Empirical Finance, LLC's Holding History (CIK: 0001572838)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 8,711 Value ($000) $3,949 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 9,493 Value ($000) $3,718 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 9,006 Value ($000) $4,009 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 8,946 Value ($000) $4,337 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 8,813 Value ($000) $3,549 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 8,916 Value ($000) $4,147 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 8,726 Value ($000) $4,090 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 9,332 Value ($000) $3,901 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 9,018 Value ($000) $3,669 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 8,970 Value ($000) $3,119 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 8,105 Value ($000) $2,852 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 7,167 Value ($000) $2,258 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 6,822 Value ($000) $1,970 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 6,277 Value ($000) $1,817 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 5,245 Value ($000) $1,478 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 4,972 Value ($000) $1,298 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 4,442 Value ($000) $975 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 3,263 Value ($000) $592 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 2,649 Value ($000) $626 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 2,649 Value ($000) $626 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 2,649 Value ($000) $626 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 2,183 Value ($000) $594 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 1,698 Value ($000) $493 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 1,482 Value ($000) $353 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 949 Value ($000) $208 Avg Close $202.38 Range $165.23 - $225.66

Q4 2016

Shares 104 Value ($000) $8 Avg Close $81.37 Range $71.46 - $97.93

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	8,711	$3,949	$431.03	$392.50 - $464.44
Q3 2025	9,493	$3,718	$417.92	$362.50 - $484.56
Q2 2025	9,006	$4,009	$460.83	$416.60 - $510.77
Q1 2025	8,946	$4,337	$466.00	$397.25 - $519.68
Q4 2024	8,813	$3,549	$463.53	$377.85 - $519.88
Q3 2024	8,916	$4,147	$480.37	$456.07 - $510.64
Q2 2024	8,726	$4,090	$434.05	$391.01 - $486.43
Q1 2024	9,332	$3,901	$422.74	$403.43 - $448.40
Q4 2023	9,018	$3,669	$369.42	$341.85 - $413.00
Q3 2023	8,970	$3,119	$349.73	$335.82 - $367.00
Q2 2023	8,105	$2,852	$336.94	$313.47 - $354.94
Q1 2023	7,167	$2,258	$299.93	$282.21 - $325.19
Q4 2022	6,822	$1,970	$304.77	$283.58 - $324.75
Q3 2022	6,277	$1,817	$287.72	$271.61 - $305.95
Q2 2022	5,245	$1,478	$267.66	$233.01 - $293.17
Q1 2022	4,972	$1,298	$237.33	$214.66 - $263.58
Q4 2021	4,442	$975	$194.45	$176.36 - $224.49
Q3 2021	3,263	$592	$195.24	$180.02 - $204.88
Q2 2021	2,649	$626	$209.17	$185.33 - $222.78
Q1 2021	2,649	$626	$219.65	$204.62 - $242.99
Q4 2020	2,649	$626	$229.44	$202.57 - $280.99
Q3 2020	2,183	$594	$275.88	$253.97 - $306.08
Q2 2020	1,698	$493	$271.12	$222.39 - $299.21
Q1 2020	1,482	$353	$229.39	$197.47 - $249.85
Q4 2019	949	$208	$202.38	$165.23 - $225.66
Q4 2016	104	$8	$81.37	$71.46 - $97.93