VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

State of Tennessee, Department of Treasury's Holding History (CIK: 0001587973)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 80,373 Value ($000) $37,767 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 86,761 Value ($000) $33,979 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 105,759 Value ($000) $47,084 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 98,349 Value ($000) $47,682 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 93,189 Value ($000) $37,527 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 100,522 Value ($000) $46,751 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 100,943 Value ($000) $47,314 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 106,685 Value ($000) $44,595 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 114,556 Value ($000) $46,612 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 105,551 Value ($000) $36,704 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 192,655 Value ($000) $67,797 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 190,968 Value ($000) $60,168 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 175,386 Value ($000) $51 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 243,463 Value ($000) $70 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 252,494 Value ($000) $71,150 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 308,979 Value ($000) $80,634 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 243,142 Value ($000) $53,394 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 193,740 Value ($000) $35,143 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 368,916 Value ($000) $74,384 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 321,224 Value ($000) $69,028 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 289,228 Value ($000) $68,356 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 464,762 Value ($000) $126,471 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 253,377 Value ($000) $73,558 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 236,150 Value ($000) $56,192 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 177,919 Value ($000) $38,955 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 163,789 Value ($000) $27,749 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 59,019 Value ($000) $10,823 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 63,970 Value ($000) $11,767 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 66,226 Value ($000) $10,974 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 409,023 Value ($000) $78,834 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 273,198 Value ($000) $46,433 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 213,090 Value ($000) $34,730 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 186,325 Value ($000) $27,923 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 173,598 Value ($000) $26,394 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 93,010 Value ($000) $11,986 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 93,051 Value ($000) $10,175 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 77,738 Value ($000) $5,727 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 104,963 Value ($000) $9,154 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 231,608 Value ($000) $19,923 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 236,470 Value ($000) $18,798 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 34,525 Value ($000) $4,344 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 99,583 Value ($000) $10,370 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 116,393 Value ($000) $14,372 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 115,090 Value ($000) $13,577 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 104,940 Value ($000) $12,467 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 108,651 Value ($000) $12,203 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 40,100 Value ($000) $3,797 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 35,800 Value ($000) $2,532 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 39,400 Value ($000) $2,927 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 40,000 Value ($000) $3,033 Avg Close $79.58 Range $73.43 - $89.96

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	80,373	$37,767	$431.03	$392.50 - $464.44
Q3 2025	86,761	$33,979	$417.92	$362.50 - $484.56
Q2 2025	105,759	$47,084	$460.83	$416.60 - $510.77
Q1 2025	98,349	$47,682	$466.00	$397.25 - $519.68
Q4 2024	93,189	$37,527	$463.53	$377.85 - $519.88
Q3 2024	100,522	$46,751	$480.37	$456.07 - $510.64
Q2 2024	100,943	$47,314	$434.05	$391.01 - $486.43
Q1 2024	106,685	$44,595	$422.74	$403.43 - $448.40
Q4 2023	114,556	$46,612	$369.42	$341.85 - $413.00
Q3 2023	105,551	$36,704	$349.73	$335.82 - $367.00
Q2 2023	192,655	$67,797	$336.94	$313.47 - $354.94
Q1 2023	190,968	$60,168	$299.93	$282.21 - $325.19
Q4 2022	175,386	$51	$304.77	$283.58 - $324.75
Q3 2022	243,463	$70	$287.72	$271.61 - $305.95
Q2 2022	252,494	$71,150	$267.66	$233.01 - $293.17
Q1 2022	308,979	$80,634	$237.33	$214.66 - $263.58
Q4 2021	243,142	$53,394	$194.45	$176.36 - $224.49
Q3 2021	193,740	$35,143	$195.24	$180.02 - $204.88
Q2 2021	368,916	$74,384	$209.17	$185.33 - $222.78
Q1 2021	321,224	$69,028	$219.65	$204.62 - $242.99
Q4 2020	289,228	$68,356	$229.44	$202.57 - $280.99
Q3 2020	464,762	$126,471	$275.88	$253.97 - $306.08
Q2 2020	253,377	$73,558	$271.12	$222.39 - $299.21
Q1 2020	236,150	$56,192	$229.39	$197.47 - $249.85
Q4 2019	177,919	$38,955	$202.38	$165.23 - $225.66
Q3 2019	163,789	$27,749	$176.91	$165.27 - $188.44
Q2 2019	59,019	$10,823	$174.82	$163.68 - $191.71
Q1 2019	63,970	$11,767	$184.70	$160.95 - $195.81
Q4 2018	66,226	$10,974	$173.27	$151.80 - $194.92
Q3 2018	409,023	$78,834	$178.07	$164.70 - $193.78
Q2 2018	273,198	$46,433	$155.01	$144.07 - $172.00
Q1 2018	213,090	$34,730	$163.34	$146.21 - $178.15
Q4 2017	186,325	$27,923	$148.07	$136.50 - $158.04
Q3 2017	173,598	$26,394	$150.51	$125.50 - $167.86
Q2 2017	93,010	$11,986	$120.38	$107.24 - $137.26
Q1 2017	93,051	$10,175	$88.04	$73.34 - $111.88
Q4 2016	77,738	$5,727	$81.37	$71.46 - $97.93
Q3 2016	104,963	$9,154	$94.50	$83.50 - $103.73
Q2 2016	231,608	$19,923	$86.41	$75.92 - $96.49
Q1 2016	236,470	$18,798	$90.45	$75.90 - $124.96
Q4 2015	34,525	$4,344	$120.72	$101.49 - $134.71
Q3 2015	99,583	$10,370	$128.47	$97.45 - $143.45
Q2 2015	116,393	$14,372	$125.98	$113.68 - $137.50
Q1 2015	115,090	$13,577	$119.81	$103.75 - $136.33
Q4 2014	104,940	$12,467	$112.63	$96.43 - $124.35
Q3 2014	108,651	$12,203	$95.21	$84.41 - $116.88
Q2 2014	40,100	$3,797	$70.12	$59.79 - $98.80
Q1 2014	35,800	$2,532	$79.20	$67.49 - $87.77
Q4 2013	39,400	$2,927	$69.64	$58.06 - $78.38
Q3 2013	40,000	$3,033	$79.58	$73.43 - $89.96