VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

JANE STREET GROUP, LLC's Holding History (CIK: 0001595888)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 11,246 Value ($000) $5,098 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 248,267 Value ($000) $97,231 Avg Close $417.92 Range $362.50 - $484.56

Q1 2025

Shares 15,008 Value ($000) $7,276 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 14,554 Value ($000) $5,861 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 54,192 Value ($000) $25,204 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 303,666 Value ($000) $142,334 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 142,608 Value ($000) $59,612 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 173,759 Value ($000) $70,701 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 60,343 Value ($000) $20,984 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 28,474 Value ($000) $10,020 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 21,739 Value ($000) $6,849 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 23,029 Value ($000) $6,650 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 33,046 Value ($000) $9,568 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 22,676 Value ($000) $6,390 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 16,924 Value ($000) $4,417 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 66,068 Value ($000) $14,509 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 135,247 Value ($000) $24,532 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 174,294 Value ($000) $35,143 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 111,180 Value ($000) $23,892 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 102,833 Value ($000) $24,303 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 51,933 Value ($000) $14,132 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 11,510 Value ($000) $3,342 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 15,321 Value ($000) $3,646 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 8,826 Value ($000) $1,933 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 14,218 Value ($000) $2,409 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 10,521 Value ($000) $1,929 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 14,028 Value ($000) $2,581 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 6,243 Value ($000) $1,035 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 36,702 Value ($000) $7,074 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 54,282 Value ($000) $9,226 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 20,397 Value ($000) $3,325 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 5,816 Value ($000) $872 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 12,255 Value ($000) $1,863 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 23,170 Value ($000) $2,986 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 24,706 Value ($000) $2,702 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 68,528 Value ($000) $5,049 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 6,311 Value ($000) $550 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 15,400 Value ($000) $1,325 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 27,017 Value ($000) $2,148 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 28,769 Value ($000) $3,620 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 22,107 Value ($000) $2,302 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 46,246 Value ($000) $5,710 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 7,025 Value ($000) $829 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 7,815 Value ($000) $928 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 1,783 Value ($000) $200 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 11,022 Value ($000) $1,044 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 12,032 Value ($000) $851 Avg Close $79.20 Range $67.49 - $87.77

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	11,246	$5,098	$431.03	$392.50 - $464.44
Q3 2025	248,267	$97,231	$417.92	$362.50 - $484.56
Q1 2025	15,008	$7,276	$466.00	$397.25 - $519.68
Q4 2024	14,554	$5,861	$463.53	$377.85 - $519.88
Q3 2024	54,192	$25,204	$480.37	$456.07 - $510.64
Q2 2024	303,666	$142,334	$434.05	$391.01 - $486.43
Q1 2024	142,608	$59,612	$422.74	$403.43 - $448.40
Q4 2023	173,759	$70,701	$369.42	$341.85 - $413.00
Q3 2023	60,343	$20,984	$349.73	$335.82 - $367.00
Q2 2023	28,474	$10,020	$336.94	$313.47 - $354.94
Q1 2023	21,739	$6,849	$299.93	$282.21 - $325.19
Q4 2022	23,029	$6,650	$304.77	$283.58 - $324.75
Q3 2022	33,046	$9,568	$287.72	$271.61 - $305.95
Q2 2022	22,676	$6,390	$267.66	$233.01 - $293.17
Q1 2022	16,924	$4,417	$237.33	$214.66 - $263.58
Q4 2021	66,068	$14,509	$194.45	$176.36 - $224.49
Q3 2021	135,247	$24,532	$195.24	$180.02 - $204.88
Q2 2021	174,294	$35,143	$209.17	$185.33 - $222.78
Q1 2021	111,180	$23,892	$219.65	$204.62 - $242.99
Q4 2020	102,833	$24,303	$229.44	$202.57 - $280.99
Q3 2020	51,933	$14,132	$275.88	$253.97 - $306.08
Q2 2020	11,510	$3,342	$271.12	$222.39 - $299.21
Q1 2020	15,321	$3,646	$229.39	$197.47 - $249.85
Q4 2019	8,826	$1,933	$202.38	$165.23 - $225.66
Q3 2019	14,218	$2,409	$176.91	$165.27 - $188.44
Q2 2019	10,521	$1,929	$174.82	$163.68 - $191.71
Q1 2019	14,028	$2,581	$184.70	$160.95 - $195.81
Q4 2018	6,243	$1,035	$173.27	$151.80 - $194.92
Q3 2018	36,702	$7,074	$178.07	$164.70 - $193.78
Q2 2018	54,282	$9,226	$155.01	$144.07 - $172.00
Q1 2018	20,397	$3,325	$163.34	$146.21 - $178.15
Q4 2017	5,816	$872	$148.07	$136.50 - $158.04
Q3 2017	12,255	$1,863	$150.51	$125.50 - $167.86
Q2 2017	23,170	$2,986	$120.38	$107.24 - $137.26
Q1 2017	24,706	$2,702	$88.04	$73.34 - $111.88
Q4 2016	68,528	$5,049	$81.37	$71.46 - $97.93
Q3 2016	6,311	$550	$94.50	$83.50 - $103.73
Q2 2016	15,400	$1,325	$86.41	$75.92 - $96.49
Q1 2016	27,017	$2,148	$90.45	$75.90 - $124.96
Q4 2015	28,769	$3,620	$120.72	$101.49 - $134.71
Q3 2015	22,107	$2,302	$128.47	$97.45 - $143.45
Q2 2015	46,246	$5,710	$125.98	$113.68 - $137.50
Q1 2015	7,025	$829	$119.81	$103.75 - $136.33
Q4 2014	7,815	$928	$112.63	$96.43 - $124.35
Q3 2014	1,783	$200	$95.21	$84.41 - $116.88
Q2 2014	11,022	$1,044	$70.12	$59.79 - $98.80
Q1 2014	12,032	$851	$79.20	$67.49 - $87.77