VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Joel Isaacson & Co., LLC's Holding History (CIK: 0001599330)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 492 Value ($000) $223 Avg Close $431.03 Range $392.50 - $464.44

Q2 2025

Shares 454 Value ($000) $202 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 454 Value ($000) $220 Avg Close $466.00 Range $397.25 - $519.68

Q2 2024

Shares 469 Value ($000) $220 Avg Close $434.05 Range $391.01 - $486.43

Q2 2015

Shares 1,150 Value ($000) $142 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 1,150 Value ($000) $136 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 1,150 Value ($000) $137 Avg Close $112.63 Range $96.43 - $124.35

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	492	$223	$431.03	$392.50 - $464.44
Q2 2025	454	$202	$460.83	$416.60 - $510.77
Q1 2025	454	$220	$466.00	$397.25 - $519.68
Q2 2024	469	$220	$434.05	$391.01 - $486.43
Q2 2015	1,150	$142	$125.98	$113.68 - $137.50
Q1 2015	1,150	$136	$119.81	$103.75 - $136.33
Q4 2014	1,150	$137	$112.63	$96.43 - $124.35