VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Rhenman & Partners Asset Management AB's Holding History (CIK: 0001599882)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 34,255 Value ($000) $15,530 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 46,955 Value ($000) $18,389 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 61,455 Value ($000) $27,360 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 66,750 Value ($000) $32,362 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 50,000 Value ($000) $20,135 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 47,750 Value ($000) $22,208 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 54,000 Value ($000) $25,311 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 56,500 Value ($000) $23,618 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 95,000 Value ($000) $38,655 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 76,500 Value ($000) $26,602 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 63,500 Value ($000) $22,346 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 83,500 Value ($000) $26,065 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 80,000 Value ($000) $23,102 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 96,000 Value ($000) $29,952 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 95,000 Value ($000) $26,770 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 89,500 Value ($000) $23,357 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 165,000 Value ($000) $36,704 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 165,000 Value ($000) $29,929 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 215,897 Value ($000) $43,531 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 168,421 Value ($000) $36,192 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 115,000 Value ($000) $27,179 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 110,000 Value ($000) $29,933 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 137,500 Value ($000) $39,918 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 115,000 Value ($000) $27,364 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 160,000 Value ($000) $35,032 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 186,000 Value ($000) $31,512 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 185,232 Value ($000) $33,968 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 144,400 Value ($000) $26,562 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 132,425 Value ($000) $21,944 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 142,465 Value ($000) $27,459 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 155,000 Value ($000) $26,344 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 150,000 Value ($000) $24,447 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 152,204 Value ($000) $22,809 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 180,000 Value ($000) $27,367 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 95,013 Value ($000) $12,244 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 95,013 Value ($000) $10,390 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 65,013 Value ($000) $4,790 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 80,013 Value ($000) $6,977,934 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 60,000 Value ($000) $5,161 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 78,000 Value ($000) $6,200 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 56,000 Value ($000) $7,046 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 105,000 Value ($000) $10,935 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 55,000 Value ($000) $6,791 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 58,000 Value ($000) $6,842 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 38,000 Value ($000) $4,514 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 43,000 Value ($000) $4,829 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 101,600 Value ($000) $9,619 Avg Close $70.12 Range $59.79 - $98.80

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	34,255	$15,530	$431.03	$392.50 - $464.44
Q3 2025	46,955	$18,389	$417.92	$362.50 - $484.56
Q2 2025	61,455	$27,360	$460.83	$416.60 - $510.77
Q1 2025	66,750	$32,362	$466.00	$397.25 - $519.68
Q4 2024	50,000	$20,135	$463.53	$377.85 - $519.88
Q3 2024	47,750	$22,208	$480.37	$456.07 - $510.64
Q2 2024	54,000	$25,311	$434.05	$391.01 - $486.43
Q1 2024	56,500	$23,618	$422.74	$403.43 - $448.40
Q4 2023	95,000	$38,655	$369.42	$341.85 - $413.00
Q3 2023	76,500	$26,602	$349.73	$335.82 - $367.00
Q2 2023	63,500	$22,346	$336.94	$313.47 - $354.94
Q1 2023	83,500	$26,065	$299.93	$282.21 - $325.19
Q4 2022	80,000	$23,102	$304.77	$283.58 - $324.75
Q3 2022	96,000	$29,952	$287.72	$271.61 - $305.95
Q2 2022	95,000	$26,770	$267.66	$233.01 - $293.17
Q1 2022	89,500	$23,357	$237.33	$214.66 - $263.58
Q4 2021	165,000	$36,704	$194.45	$176.36 - $224.49
Q3 2021	165,000	$29,929	$195.24	$180.02 - $204.88
Q2 2021	215,897	$43,531	$209.17	$185.33 - $222.78
Q1 2021	168,421	$36,192	$219.65	$204.62 - $242.99
Q4 2020	115,000	$27,179	$229.44	$202.57 - $280.99
Q3 2020	110,000	$29,933	$275.88	$253.97 - $306.08
Q2 2020	137,500	$39,918	$271.12	$222.39 - $299.21
Q1 2020	115,000	$27,364	$229.39	$197.47 - $249.85
Q4 2019	160,000	$35,032	$202.38	$165.23 - $225.66
Q3 2019	186,000	$31,512	$176.91	$165.27 - $188.44
Q2 2019	185,232	$33,968	$174.82	$163.68 - $191.71
Q1 2019	144,400	$26,562	$184.70	$160.95 - $195.81
Q4 2018	132,425	$21,944	$173.27	$151.80 - $194.92
Q3 2018	142,465	$27,459	$178.07	$164.70 - $193.78
Q2 2018	155,000	$26,344	$155.01	$144.07 - $172.00
Q1 2018	150,000	$24,447	$163.34	$146.21 - $178.15
Q4 2017	152,204	$22,809	$148.07	$136.50 - $158.04
Q3 2017	180,000	$27,367	$150.51	$125.50 - $167.86
Q2 2017	95,013	$12,244	$120.38	$107.24 - $137.26
Q1 2017	95,013	$10,390	$88.04	$73.34 - $111.88
Q4 2016	65,013	$4,790	$81.37	$71.46 - $97.93
Q3 2016	80,013	$6,977,934	$94.50	$83.50 - $103.73
Q2 2016	60,000	$5,161	$86.41	$75.92 - $96.49
Q1 2016	78,000	$6,200	$90.45	$75.90 - $124.96
Q4 2015	56,000	$7,046	$120.72	$101.49 - $134.71
Q3 2015	105,000	$10,935	$128.47	$97.45 - $143.45
Q2 2015	55,000	$6,791	$125.98	$113.68 - $137.50
Q1 2015	58,000	$6,842	$119.81	$103.75 - $136.33
Q4 2014	38,000	$4,514	$112.63	$96.43 - $124.35
Q3 2014	43,000	$4,829	$95.21	$84.41 - $116.88
Q2 2014	101,600	$9,619	$70.12	$59.79 - $98.80