VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Graticule Asia Macro Advisors LLC's Holding History (CIK: 0001619390)

Note: Option positions (PUT/CALL) are excluded.

Q3 2017

Shares 41,300 Value ($000) $6,279 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 59,855 Value ($000) $7,714 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 74,287 Value ($000) $8,123 Avg Close $88.04 Range $73.34 - $111.88

Q1 2016

Shares 112,261 Value ($000) $8,923 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 41,628 Value ($000) $5,239 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 15,000 Value ($000) $1,562 Avg Close $128.47 Range $97.45 - $143.45

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2017	41,300	$6,279	$150.51	$125.50 - $167.86
Q2 2017	59,855	$7,714	$120.38	$107.24 - $137.26
Q1 2017	74,287	$8,123	$88.04	$73.34 - $111.88
Q1 2016	112,261	$8,923	$90.45	$75.90 - $124.96
Q4 2015	41,628	$5,239	$120.72	$101.49 - $134.71
Q3 2015	15,000	$1,562	$128.47	$97.45 - $143.45