VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Engineers Gate Manager LP's Holding History (CIK: 0001620220)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 4,664 Value ($000) $2,114 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 14,843 Value ($000) $5,813 Avg Close $417.92 Range $362.50 - $484.56

Q4 2024

Shares 11,599 Value ($000) $4,671 Avg Close $463.53 Range $377.85 - $519.88

Q2 2024

Shares 13,386 Value ($000) $6,274 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 12,505 Value ($000) $5,227 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 7,619 Value ($000) $3,100 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 8,715 Value ($000) $3,031 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 3,293 Value ($000) $1,159 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 2,514 Value ($000) $792 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 30,297 Value ($000) $8,749 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 2,338 Value ($000) $677 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 5,111 Value ($000) $1,440 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 7,264 Value ($000) $1,896 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 9,942 Value ($000) $2,183 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 43,744 Value ($000) $7,935 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 26,893 Value ($000) $5,422 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 2,593 Value ($000) $557 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 2,579 Value ($000) $610 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 11,820 Value ($000) $3,216 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 2,410 Value ($000) $700 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 2,428 Value ($000) $578 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 15,385 Value ($000) $3,369 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 3,731 Value ($000) $632 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 14,903 Value ($000) $2,732 Avg Close $174.82 Range $163.68 - $191.71

Q1 2017

Shares 4,300 Value ($000) $470 Avg Close $88.04 Range $73.34 - $111.88

Q1 2016

Shares 12,638 Value ($000) $1,005 Avg Close $90.45 Range $75.90 - $124.96

Q2 2015

Shares 2,100 Value ($000) $259 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 1,956 Value ($000) $231 Avg Close $119.81 Range $103.75 - $136.33

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	4,664	$2,114	$431.03	$392.50 - $464.44
Q3 2025	14,843	$5,813	$417.92	$362.50 - $484.56
Q4 2024	11,599	$4,671	$463.53	$377.85 - $519.88
Q2 2024	13,386	$6,274	$434.05	$391.01 - $486.43
Q1 2024	12,505	$5,227	$422.74	$403.43 - $448.40
Q4 2023	7,619	$3,100	$369.42	$341.85 - $413.00
Q3 2023	8,715	$3,031	$349.73	$335.82 - $367.00
Q2 2023	3,293	$1,159	$336.94	$313.47 - $354.94
Q1 2023	2,514	$792	$299.93	$282.21 - $325.19
Q4 2022	30,297	$8,749	$304.77	$283.58 - $324.75
Q3 2022	2,338	$677	$287.72	$271.61 - $305.95
Q2 2022	5,111	$1,440	$267.66	$233.01 - $293.17
Q1 2022	7,264	$1,896	$237.33	$214.66 - $263.58
Q4 2021	9,942	$2,183	$194.45	$176.36 - $224.49
Q3 2021	43,744	$7,935	$195.24	$180.02 - $204.88
Q2 2021	26,893	$5,422	$209.17	$185.33 - $222.78
Q1 2021	2,593	$557	$219.65	$204.62 - $242.99
Q4 2020	2,579	$610	$229.44	$202.57 - $280.99
Q3 2020	11,820	$3,216	$275.88	$253.97 - $306.08
Q2 2020	2,410	$700	$271.12	$222.39 - $299.21
Q1 2020	2,428	$578	$229.39	$197.47 - $249.85
Q4 2019	15,385	$3,369	$202.38	$165.23 - $225.66
Q3 2019	3,731	$632	$176.91	$165.27 - $188.44
Q2 2019	14,903	$2,732	$174.82	$163.68 - $191.71
Q1 2017	4,300	$470	$88.04	$73.34 - $111.88
Q1 2016	12,638	$1,005	$90.45	$75.90 - $124.96
Q2 2015	2,100	$259	$125.98	$113.68 - $137.50
Q1 2015	1,956	$231	$119.81	$103.75 - $136.33