VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

NORTHWESTERN MUTUAL INVESTMENT MANAGEMENT COMPANY, LLC's Holding History (CIK: 0001629649)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 8,107 Value ($000) $3,675 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 8,171 Value ($000) $3,200 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 8,193 Value ($000) $3,648 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 8,167 Value ($000) $3,960 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 8,177 Value ($000) $3,293 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 8,181 Value ($000) $3,805 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 8,213 Value ($000) $3,850 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 8,178 Value ($000) $3,418 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 8,157 Value ($000) $3,319 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 8,146 Value ($000) $2,833 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 8,124 Value ($000) $2,859 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 8,081 Value ($000) $2,546 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 8,045 Value ($000) $2,323 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 9,526 Value ($000) $2,758 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 11,341 Value ($000) $3,196 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 11,263 Value ($000) $2,939 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 12,616 Value ($000) $2,770 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 12,998 Value ($000) $2,358 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 11,756 Value ($000) $2,370 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 11,785 Value ($000) $2,532 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 14,271 Value ($000) $3,373 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 14,244 Value ($000) $4,135 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 14,244 Value ($000) $4,135 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 13,400 Value ($000) $3,189 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 9,990 Value ($000) $2,187 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 9,788 Value ($000) $1,658 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 9,715 Value ($000) $1,782 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 38,849 Value ($000) $7,146 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 38,514 Value ($000) $6,382 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 44,721 Value ($000) $8,620 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 48,798 Value ($000) $8,294 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 46,215 Value ($000) $7,532 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 57,124 Value ($000) $8,561 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 56,525 Value ($000) $8,594 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 57,155 Value ($000) $7,366 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 50,220 Value ($000) $5,492 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 13,369 Value ($000) $985 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 24,514 Value ($000) $2,138 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 9,435 Value ($000) $812 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 9,407 Value ($000) $748 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 9,334 Value ($000) $1,174 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 9,012 Value ($000) $939 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 8,955 Value ($000) $1,106 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 34,952 Value ($000) $4,123 Avg Close $119.81 Range $103.75 - $136.33

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	8,107	$3,675	$431.03	$392.50 - $464.44
Q3 2025	8,171	$3,200	$417.92	$362.50 - $484.56
Q2 2025	8,193	$3,648	$460.83	$416.60 - $510.77
Q1 2025	8,167	$3,960	$466.00	$397.25 - $519.68
Q4 2024	8,177	$3,293	$463.53	$377.85 - $519.88
Q3 2024	8,181	$3,805	$480.37	$456.07 - $510.64
Q2 2024	8,213	$3,850	$434.05	$391.01 - $486.43
Q1 2024	8,178	$3,418	$422.74	$403.43 - $448.40
Q4 2023	8,157	$3,319	$369.42	$341.85 - $413.00
Q3 2023	8,146	$2,833	$349.73	$335.82 - $367.00
Q2 2023	8,124	$2,859	$336.94	$313.47 - $354.94
Q1 2023	8,081	$2,546	$299.93	$282.21 - $325.19
Q4 2022	8,045	$2,323	$304.77	$283.58 - $324.75
Q3 2022	9,526	$2,758	$287.72	$271.61 - $305.95
Q2 2022	11,341	$3,196	$267.66	$233.01 - $293.17
Q1 2022	11,263	$2,939	$237.33	$214.66 - $263.58
Q4 2021	12,616	$2,770	$194.45	$176.36 - $224.49
Q3 2021	12,998	$2,358	$195.24	$180.02 - $204.88
Q2 2021	11,756	$2,370	$209.17	$185.33 - $222.78
Q1 2021	11,785	$2,532	$219.65	$204.62 - $242.99
Q4 2020	14,271	$3,373	$229.44	$202.57 - $280.99
Q3 2020	14,244	$4,135	$275.88	$253.97 - $306.08
Q2 2020	14,244	$4,135	$271.12	$222.39 - $299.21
Q1 2020	13,400	$3,189	$229.39	$197.47 - $249.85
Q4 2019	9,990	$2,187	$202.38	$165.23 - $225.66
Q3 2019	9,788	$1,658	$176.91	$165.27 - $188.44
Q2 2019	9,715	$1,782	$174.82	$163.68 - $191.71
Q1 2019	38,849	$7,146	$184.70	$160.95 - $195.81
Q4 2018	38,514	$6,382	$173.27	$151.80 - $194.92
Q3 2018	44,721	$8,620	$178.07	$164.70 - $193.78
Q2 2018	48,798	$8,294	$155.01	$144.07 - $172.00
Q1 2018	46,215	$7,532	$163.34	$146.21 - $178.15
Q4 2017	57,124	$8,561	$148.07	$136.50 - $158.04
Q3 2017	56,525	$8,594	$150.51	$125.50 - $167.86
Q2 2017	57,155	$7,366	$120.38	$107.24 - $137.26
Q1 2017	50,220	$5,492	$88.04	$73.34 - $111.88
Q4 2016	13,369	$985	$81.37	$71.46 - $97.93
Q3 2016	24,514	$2,138	$94.50	$83.50 - $103.73
Q2 2016	9,435	$812	$86.41	$75.92 - $96.49
Q1 2016	9,407	$748	$90.45	$75.90 - $124.96
Q4 2015	9,334	$1,174	$120.72	$101.49 - $134.71
Q3 2015	9,012	$939	$128.47	$97.45 - $143.45
Q2 2015	8,955	$1,106	$125.98	$113.68 - $137.50
Q1 2015	34,952	$4,123	$119.81	$103.75 - $136.33