VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC's Holding History (CIK: 0001644956)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 39,735 Value ($000) $18,014 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 596 Value ($000) $233 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 22,608 Value ($000) $10,065 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 79,332 Value ($000) $38,462 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 77,532 Value ($000) $31,222 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 76,549 Value ($000) $35,601 Avg Close $480.37 Range $456.07 - $510.64

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	39,735	$18,014	$431.03	$392.50 - $464.44
Q3 2025	596	$233	$417.92	$362.50 - $484.56
Q2 2025	22,608	$10,065	$460.83	$416.60 - $510.77
Q1 2025	79,332	$38,462	$466.00	$397.25 - $519.68
Q4 2024	77,532	$31,222	$463.53	$377.85 - $519.88
Q3 2024	76,549	$35,601	$480.37	$456.07 - $510.64