VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

EDMOND DE ROTHSCHILD HOLDING S.A.'s Holding History (CIK: 0001649647)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 191 Value ($000) $87 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 191 Value ($000) $75 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 191 Value ($000) $85 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 214 Value ($000) $104 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 393 Value ($000) $158 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 1,292 Value ($000) $601 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 1,252 Value ($000) $587 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 1,454 Value ($000) $608 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 1,583 Value ($000) $644 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 1,704 Value ($000) $593 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 1,851 Value ($000) $651 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 1,881 Value ($000) $593 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 6,527 Value ($000) $1,885 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 6,219 Value ($000) $1,801 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 13,086 Value ($000) $3,688 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 17,729 Value ($000) $4,626 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 20,039 Value ($000) $4,401 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 25,716 Value ($000) $4,665 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 27,777 Value ($000) $5,601 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 27,271 Value ($000) $5,860 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 25,328 Value ($000) $5,986 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 10,117 Value ($000) $2,753 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 10,117 Value ($000) $2,937 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 214 Value ($000) $51 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 214 Value ($000) $47 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 214 Value ($000) $36 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 214 Value ($000) $39 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 214 Value ($000) $39 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 214 Value ($000) $35 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 214 Value ($000) $41 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 214 Value ($000) $36 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 214 Value ($000) $35 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 11,814 Value ($000) $1,770 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 25,964 Value ($000) $3,948 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 155,364 Value ($000) $20,022 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 205,364 Value ($000) $22,456 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 241,864 Value ($000) $17,818 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 215,864 Value ($000) $18,825 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 225,064 Value ($000) $19,360 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 188,514 Value ($000) $14,985 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 130,214 Value ($000) $16,385 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 115,214 Value ($000) $11,998 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 214 Value ($000) $26 Avg Close $125.98 Range $113.68 - $137.50

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	191	$87	$431.03	$392.50 - $464.44
Q3 2025	191	$75	$417.92	$362.50 - $484.56
Q2 2025	191	$85	$460.83	$416.60 - $510.77
Q1 2025	214	$104	$466.00	$397.25 - $519.68
Q4 2024	393	$158	$463.53	$377.85 - $519.88
Q3 2024	1,292	$601	$480.37	$456.07 - $510.64
Q2 2024	1,252	$587	$434.05	$391.01 - $486.43
Q1 2024	1,454	$608	$422.74	$403.43 - $448.40
Q4 2023	1,583	$644	$369.42	$341.85 - $413.00
Q3 2023	1,704	$593	$349.73	$335.82 - $367.00
Q2 2023	1,851	$651	$336.94	$313.47 - $354.94
Q1 2023	1,881	$593	$299.93	$282.21 - $325.19
Q4 2022	6,527	$1,885	$304.77	$283.58 - $324.75
Q3 2022	6,219	$1,801	$287.72	$271.61 - $305.95
Q2 2022	13,086	$3,688	$267.66	$233.01 - $293.17
Q1 2022	17,729	$4,626	$237.33	$214.66 - $263.58
Q4 2021	20,039	$4,401	$194.45	$176.36 - $224.49
Q3 2021	25,716	$4,665	$195.24	$180.02 - $204.88
Q2 2021	27,777	$5,601	$209.17	$185.33 - $222.78
Q1 2021	27,271	$5,860	$219.65	$204.62 - $242.99
Q4 2020	25,328	$5,986	$229.44	$202.57 - $280.99
Q3 2020	10,117	$2,753	$275.88	$253.97 - $306.08
Q2 2020	10,117	$2,937	$271.12	$222.39 - $299.21
Q1 2020	214	$51	$229.39	$197.47 - $249.85
Q4 2019	214	$47	$202.38	$165.23 - $225.66
Q3 2019	214	$36	$176.91	$165.27 - $188.44
Q2 2019	214	$39	$174.82	$163.68 - $191.71
Q1 2019	214	$39	$184.70	$160.95 - $195.81
Q4 2018	214	$35	$173.27	$151.80 - $194.92
Q3 2018	214	$41	$178.07	$164.70 - $193.78
Q2 2018	214	$36	$155.01	$144.07 - $172.00
Q1 2018	214	$35	$163.34	$146.21 - $178.15
Q4 2017	11,814	$1,770	$148.07	$136.50 - $158.04
Q3 2017	25,964	$3,948	$150.51	$125.50 - $167.86
Q2 2017	155,364	$20,022	$120.38	$107.24 - $137.26
Q1 2017	205,364	$22,456	$88.04	$73.34 - $111.88
Q4 2016	241,864	$17,818	$81.37	$71.46 - $97.93
Q3 2016	215,864	$18,825	$94.50	$83.50 - $103.73
Q2 2016	225,064	$19,360	$86.41	$75.92 - $96.49
Q1 2016	188,514	$14,985	$90.45	$75.90 - $124.96
Q4 2015	130,214	$16,385	$120.72	$101.49 - $134.71
Q3 2015	115,214	$11,998	$128.47	$97.45 - $143.45
Q2 2015	214	$26	$125.98	$113.68 - $137.50