VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Cetera Investment Advisers's Holding History (CIK: 0001666741)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 75,013 Value ($000) $34,008 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 77,714 Value ($000) $30,436 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 60,196 Value ($000) $26,799 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 64,774 Value ($000) $31,404 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 53,957 Value ($000) $21,729 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 53,629 Value ($000) $24,942 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 52,013 Value ($000) $24,379 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 50,867 Value ($000) $21,263 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 17,337 Value ($000) $7,054 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 15,806 Value ($000) $5,496 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 15,381 Value ($000) $5,413 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 13,917 Value ($000) $4,385 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 14,977 Value ($000) $4,325 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 9,777 Value ($000) $2,831 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 10,718 Value ($000) $3,020 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 14,114 Value ($000) $3,683 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 13,570 Value ($000) $2,980 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 13,882 Value ($000) $2,518 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 14,701 Value ($000) $2,964 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 13,833 Value ($000) $2,973 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 17,201 Value ($000) $4,065 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 5,044 Value ($000) $1,373 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 1,306 Value ($000) $379 Avg Close $271.12 Range $222.39 - $299.21

Q3 2018

Shares 1,128 Value ($000) $217 Avg Close $178.07 Range $164.70 - $193.78

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	75,013	$34,008	$431.03	$392.50 - $464.44
Q3 2025	77,714	$30,436	$417.92	$362.50 - $484.56
Q2 2025	60,196	$26,799	$460.83	$416.60 - $510.77
Q1 2025	64,774	$31,404	$466.00	$397.25 - $519.68
Q4 2024	53,957	$21,729	$463.53	$377.85 - $519.88
Q3 2024	53,629	$24,942	$480.37	$456.07 - $510.64
Q2 2024	52,013	$24,379	$434.05	$391.01 - $486.43
Q1 2024	50,867	$21,263	$422.74	$403.43 - $448.40
Q4 2023	17,337	$7,054	$369.42	$341.85 - $413.00
Q3 2023	15,806	$5,496	$349.73	$335.82 - $367.00
Q2 2023	15,381	$5,413	$336.94	$313.47 - $354.94
Q1 2023	13,917	$4,385	$299.93	$282.21 - $325.19
Q4 2022	14,977	$4,325	$304.77	$283.58 - $324.75
Q3 2022	9,777	$2,831	$287.72	$271.61 - $305.95
Q2 2022	10,718	$3,020	$267.66	$233.01 - $293.17
Q1 2022	14,114	$3,683	$237.33	$214.66 - $263.58
Q4 2021	13,570	$2,980	$194.45	$176.36 - $224.49
Q3 2021	13,882	$2,518	$195.24	$180.02 - $204.88
Q2 2021	14,701	$2,964	$209.17	$185.33 - $222.78
Q1 2021	13,833	$2,973	$219.65	$204.62 - $242.99
Q4 2020	17,201	$4,065	$229.44	$202.57 - $280.99
Q3 2020	5,044	$1,373	$275.88	$253.97 - $306.08
Q2 2020	1,306	$379	$271.12	$222.39 - $299.21
Q3 2018	1,128	$217	$178.07	$164.70 - $193.78