VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Signature Wealth Management Group's Holding History (CIK: 0001736666)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 4,324 Value ($000) $1,960 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 4,111 Value ($000) $1,610 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 4,244 Value ($000) $1,889 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 4,218 Value ($000) $2,045 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 4,075 Value ($000) $1,641 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 3,972 Value ($000) $1,847 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 3,757 Value ($000) $1,761 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 1,641 Value ($000) $647 Avg Close $422.74 Range $403.43 - $448.40

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	4,324	$1,960	$431.03	$392.50 - $464.44
Q3 2025	4,111	$1,610	$417.92	$362.50 - $484.56
Q2 2025	4,244	$1,889	$460.83	$416.60 - $510.77
Q1 2025	4,218	$2,045	$466.00	$397.25 - $519.68
Q4 2024	4,075	$1,641	$463.53	$377.85 - $519.88
Q3 2024	3,972	$1,847	$480.37	$456.07 - $510.64
Q2 2024	3,757	$1,761	$434.05	$391.01 - $486.43
Q1 2024	1,641	$647	$422.74	$403.43 - $448.40