VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

WORLDQUANT MILLENNIUM ADVISORS LLC's Holding History (CIK: 0001745981)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 108,002 Value ($000) $48,964 Avg Close $431.03 Range $392.50 - $464.44

Q1 2024

Shares 117,983 Value ($000) $49,318 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 206,605 Value ($000) $84,066 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 138,310 Value ($000) $48,096 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 140,665 Value ($000) $49,501 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 753 Value ($000) $0 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 88,282 Value ($000) $25 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 31,762 Value ($000) $9,196 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 8,707 Value ($000) $2,454 Avg Close $267.66 Range $233.01 - $293.17

Q3 2021

Shares 122,737 Value ($000) $22,263 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 136,463 Value ($000) $27,515 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 105,100 Value ($000) $22,585 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 95,322 Value ($000) $22,528 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 95,322 Value ($000) $25,939 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 94,299 Value ($000) $27,376 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 36,127 Value ($000) $8,596 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 42,197 Value ($000) $9,239 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 180,086 Value ($000) $30,510 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 458,226 Value ($000) $84,029 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 394,285 Value ($000) $72,529 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 353,483 Value ($000) $58,576 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 267,043 Value ($000) $51,470 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 170,712 Value ($000) $29,014 Avg Close $155.01 Range $144.07 - $172.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	108,002	$48,964	$431.03	$392.50 - $464.44
Q1 2024	117,983	$49,318	$422.74	$403.43 - $448.40
Q4 2023	206,605	$84,066	$369.42	$341.85 - $413.00
Q3 2023	138,310	$48,096	$349.73	$335.82 - $367.00
Q2 2023	140,665	$49,501	$336.94	$313.47 - $354.94
Q1 2023	753	$0	$299.93	$282.21 - $325.19
Q4 2022	88,282	$25	$304.77	$283.58 - $324.75
Q3 2022	31,762	$9,196	$287.72	$271.61 - $305.95
Q2 2022	8,707	$2,454	$267.66	$233.01 - $293.17
Q3 2021	122,737	$22,263	$195.24	$180.02 - $204.88
Q2 2021	136,463	$27,515	$209.17	$185.33 - $222.78
Q1 2021	105,100	$22,585	$219.65	$204.62 - $242.99
Q4 2020	95,322	$22,528	$229.44	$202.57 - $280.99
Q3 2020	95,322	$25,939	$275.88	$253.97 - $306.08
Q2 2020	94,299	$27,376	$271.12	$222.39 - $299.21
Q1 2020	36,127	$8,596	$229.39	$197.47 - $249.85
Q4 2019	42,197	$9,239	$202.38	$165.23 - $225.66
Q3 2019	180,086	$30,510	$176.91	$165.27 - $188.44
Q2 2019	458,226	$84,029	$174.82	$163.68 - $191.71
Q1 2019	394,285	$72,529	$184.70	$160.95 - $195.81
Q4 2018	353,483	$58,576	$173.27	$151.80 - $194.92
Q3 2018	267,043	$51,470	$178.07	$164.70 - $193.78
Q2 2018	170,712	$29,014	$155.01	$144.07 - $172.00