VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Cresset Asset Management, LLC's Holding History (CIK: 0001761013)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 7,555 Value ($000) $3,425 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 7,592 Value ($000) $2,973 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 12,227 Value ($000) $5,443 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 14,327 Value ($000) $6,946 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 16,018 Value ($000) $6,450 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 24,043 Value ($000) $11,182 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 16,039 Value ($000) $7,518 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 12,034 Value ($000) $5,030 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 11,073 Value ($000) $4,505 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 9,265 Value ($000) $3,222 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 10,499 Value ($000) $3,695 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 1,389 Value ($000) $438 Avg Close $299.93 Range $282.21 - $325.19

Q3 2022

Shares 1,812 Value ($000) $524 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 2,157 Value ($000) $605 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 3,007 Value ($000) $785 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 2,554 Value ($000) $560 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 3,019 Value ($000) $548 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 2,517 Value ($000) $508 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 2,365 Value ($000) $508 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 1,780 Value ($000) $421 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 2,097 Value ($000) $570 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 1,932 Value ($000) $561 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 1,390 Value ($000) $331 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 1,137 Value ($000) $249 Avg Close $202.38 Range $165.23 - $225.66

Q2 2019

Shares 1,212 Value ($000) $222 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 1,108 Value ($000) $204 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 506 Value ($000) $84 Avg Close $173.27 Range $151.80 - $194.92

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	7,555	$3,425	$431.03	$392.50 - $464.44
Q3 2025	7,592	$2,973	$417.92	$362.50 - $484.56
Q2 2025	12,227	$5,443	$460.83	$416.60 - $510.77
Q1 2025	14,327	$6,946	$466.00	$397.25 - $519.68
Q4 2024	16,018	$6,450	$463.53	$377.85 - $519.88
Q3 2024	24,043	$11,182	$480.37	$456.07 - $510.64
Q2 2024	16,039	$7,518	$434.05	$391.01 - $486.43
Q1 2024	12,034	$5,030	$422.74	$403.43 - $448.40
Q4 2023	11,073	$4,505	$369.42	$341.85 - $413.00
Q3 2023	9,265	$3,222	$349.73	$335.82 - $367.00
Q2 2023	10,499	$3,695	$336.94	$313.47 - $354.94
Q1 2023	1,389	$438	$299.93	$282.21 - $325.19
Q3 2022	1,812	$524	$287.72	$271.61 - $305.95
Q2 2022	2,157	$605	$267.66	$233.01 - $293.17
Q1 2022	3,007	$785	$237.33	$214.66 - $263.58
Q4 2021	2,554	$560	$194.45	$176.36 - $224.49
Q3 2021	3,019	$548	$195.24	$180.02 - $204.88
Q2 2021	2,517	$508	$209.17	$185.33 - $222.78
Q1 2021	2,365	$508	$219.65	$204.62 - $242.99
Q4 2020	1,780	$421	$229.44	$202.57 - $280.99
Q3 2020	2,097	$570	$275.88	$253.97 - $306.08
Q2 2020	1,932	$561	$271.12	$222.39 - $299.21
Q1 2020	1,390	$331	$229.39	$197.47 - $249.85
Q4 2019	1,137	$249	$202.38	$165.23 - $225.66
Q2 2019	1,212	$222	$174.82	$163.68 - $191.71
Q1 2019	1,108	$204	$184.70	$160.95 - $195.81
Q4 2018	506	$84	$173.27	$151.80 - $194.92