VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Vanguard Personalized Indexing Management, LLC's Holding History (CIK: 0001767306)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 39,165 Value ($000) $17,756 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 37,000 Value ($000) $14,492 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 38,491 Value ($000) $17,138 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 35,762 Value ($000) $17,338 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 31,178 Value ($000) $12,555 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 31,797 Value ($000) $14,788 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 29,457 Value ($000) $13,686 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 24,987 Value ($000) $10,445 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 24,078 Value ($000) $9,797 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 25,755 Value ($000) $8,956 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 24,260 Value ($000) $8,537 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 22,376 Value ($000) $7,050 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 20,695 Value ($000) $5,976 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 20,164 Value ($000) $5,838 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 18,714 Value ($000) $5,273 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 13,905 Value ($000) $3,629 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 10,495 Value ($000) $2,305 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 4,756 Value ($000) $863 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 2,521 Value ($000) $508 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 4,270 Value ($000) $918 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 3,054 Value ($000) $722 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 3,104 Value ($000) $845 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 1,688 Value ($000) $490 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 1,217 Value ($000) $290 Avg Close $229.39 Range $197.47 - $249.85

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	39,165	$17,756	$431.03	$392.50 - $464.44
Q3 2025	37,000	$14,492	$417.92	$362.50 - $484.56
Q2 2025	38,491	$17,138	$460.83	$416.60 - $510.77
Q1 2025	35,762	$17,338	$466.00	$397.25 - $519.68
Q4 2024	31,178	$12,555	$463.53	$377.85 - $519.88
Q3 2024	31,797	$14,788	$480.37	$456.07 - $510.64
Q2 2024	29,457	$13,686	$434.05	$391.01 - $486.43
Q1 2024	24,987	$10,445	$422.74	$403.43 - $448.40
Q4 2023	24,078	$9,797	$369.42	$341.85 - $413.00
Q3 2023	25,755	$8,956	$349.73	$335.82 - $367.00
Q2 2023	24,260	$8,537	$336.94	$313.47 - $354.94
Q1 2023	22,376	$7,050	$299.93	$282.21 - $325.19
Q4 2022	20,695	$5,976	$304.77	$283.58 - $324.75
Q3 2022	20,164	$5,838	$287.72	$271.61 - $305.95
Q2 2022	18,714	$5,273	$267.66	$233.01 - $293.17
Q1 2022	13,905	$3,629	$237.33	$214.66 - $263.58
Q4 2021	10,495	$2,305	$194.45	$176.36 - $224.49
Q3 2021	4,756	$863	$195.24	$180.02 - $204.88
Q2 2021	2,521	$508	$209.17	$185.33 - $222.78
Q1 2021	4,270	$918	$219.65	$204.62 - $242.99
Q4 2020	3,054	$722	$229.44	$202.57 - $280.99
Q3 2020	3,104	$845	$275.88	$253.97 - $306.08
Q2 2020	1,688	$490	$271.12	$222.39 - $299.21
Q1 2020	1,217	$290	$229.39	$197.47 - $249.85