VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

OSTRUM ASSET MANAGEMENT's Holding History (CIK: 0001767945)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 4,249 Value ($000) $1,926 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 5,419 Value ($000) $2,122 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 5,894 Value ($000) $2,624 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 6,346 Value ($000) $3,077 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 6,359 Value ($000) $2,561 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 5,273 Value ($000) $2,452 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 7,428 Value ($000) $3,482 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 9,321 Value ($000) $3,896 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 9,306 Value ($000) $3,787 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 8,829 Value ($000) $3,070 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 8,889 Value ($000) $3,128 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 8,881 Value ($000) $2,798 Avg Close $299.93 Range $282.21 - $325.19

Q3 2020

Shares 13,405 Value ($000) $3,648 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 12,395 Value ($000) $3,598 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 10,695 Value ($000) $2,545 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 9,595 Value ($000) $2,101 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 9,595 Value ($000) $1,626 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 8,695 Value ($000) $1,594 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 3,653 Value ($000) $672 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 3,653 Value ($000) $605 Avg Close $173.27 Range $151.80 - $194.92

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	4,249	$1,926	$431.03	$392.50 - $464.44
Q3 2025	5,419	$2,122	$417.92	$362.50 - $484.56
Q2 2025	5,894	$2,624	$460.83	$416.60 - $510.77
Q1 2025	6,346	$3,077	$466.00	$397.25 - $519.68
Q4 2024	6,359	$2,561	$463.53	$377.85 - $519.88
Q3 2024	5,273	$2,452	$480.37	$456.07 - $510.64
Q2 2024	7,428	$3,482	$434.05	$391.01 - $486.43
Q1 2024	9,321	$3,896	$422.74	$403.43 - $448.40
Q4 2023	9,306	$3,787	$369.42	$341.85 - $413.00
Q3 2023	8,829	$3,070	$349.73	$335.82 - $367.00
Q2 2023	8,889	$3,128	$336.94	$313.47 - $354.94
Q1 2023	8,881	$2,798	$299.93	$282.21 - $325.19
Q3 2020	13,405	$3,648	$275.88	$253.97 - $306.08
Q2 2020	12,395	$3,598	$271.12	$222.39 - $299.21
Q1 2020	10,695	$2,545	$229.39	$197.47 - $249.85
Q4 2019	9,595	$2,101	$202.38	$165.23 - $225.66
Q3 2019	9,595	$1,626	$176.91	$165.27 - $188.44
Q2 2019	8,695	$1,594	$174.82	$163.68 - $191.71
Q1 2019	3,653	$672	$184.70	$160.95 - $195.81
Q4 2018	3,653	$605	$173.27	$151.80 - $194.92