VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Avidity Partners Management LP's Holding History (CIK: 0001791827)

Note: Option positions (PUT/CALL) are excluded.

Q4 2022

Shares 172,000 Value ($000) $49,670 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 512,800 Value ($000) $148,476 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 793,000 Value ($000) $223,459 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 545,600 Value ($000) $142,385 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 280,000 Value ($000) $61,488 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 926,400 Value ($000) $168,040 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 950,000 Value ($000) $191,549 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 310,900 Value ($000) $66,809 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 147,300 Value ($000) $34,813 Avg Close $229.44 Range $202.57 - $280.99

Q1 2020

Shares 34,000 Value ($000) $8,090 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 40,000 Value ($000) $8,758 Avg Close $202.38 Range $165.23 - $225.66

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2022	172,000	$49,670	$304.77	$283.58 - $324.75
Q3 2022	512,800	$148,476	$287.72	$271.61 - $305.95
Q2 2022	793,000	$223,459	$267.66	$233.01 - $293.17
Q1 2022	545,600	$142,385	$237.33	$214.66 - $263.58
Q4 2021	280,000	$61,488	$194.45	$176.36 - $224.49
Q3 2021	926,400	$168,040	$195.24	$180.02 - $204.88
Q2 2021	950,000	$191,549	$209.17	$185.33 - $222.78
Q1 2021	310,900	$66,809	$219.65	$204.62 - $242.99
Q4 2020	147,300	$34,813	$229.44	$202.57 - $280.99
Q1 2020	34,000	$8,090	$229.39	$197.47 - $249.85
Q4 2019	40,000	$8,758	$202.38	$165.23 - $225.66