VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

J. Safra Sarasin Holding AG's Holding History (CIK: 0001890222)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 3,000 Value ($000) $1,360 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 3,827 Value ($000) $1,499 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 3,000 Value ($000) $1,336 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 3,946 Value ($000) $1,913 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 55,896 Value ($000) $22,509 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 60,142 Value ($000) $27,971 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 67,620 Value ($000) $31,695 Avg Close $434.05 Range $391.01 - $486.43

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	3,000	$1,360	$431.03	$392.50 - $464.44
Q3 2025	3,827	$1,499	$417.92	$362.50 - $484.56
Q2 2025	3,000	$1,336	$460.83	$416.60 - $510.77
Q1 2025	3,946	$1,913	$466.00	$397.25 - $519.68
Q4 2024	55,896	$22,509	$463.53	$377.85 - $519.88
Q3 2024	60,142	$27,971	$480.37	$456.07 - $510.64
Q2 2024	67,620	$31,695	$434.05	$391.01 - $486.43