VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

iSAM Funds (UK) Ltd's Holding History (CIK: 0001919867)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 3,221 Value ($000) $1,460 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 1,250 Value ($000) $490 Avg Close $417.92 Range $362.50 - $484.56

Q3 2024

Shares 1,051 Value ($000) $489 Avg Close $480.37 Range $456.07 - $510.64

Q1 2024

Shares 2,015 Value ($000) $842 Avg Close $422.74 Range $403.43 - $448.40

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	3,221	$1,460	$431.03	$392.50 - $464.44
Q3 2025	1,250	$490	$417.92	$362.50 - $484.56
Q3 2024	1,051	$489	$480.37	$456.07 - $510.64
Q1 2024	2,015	$842	$422.74	$403.43 - $448.40