VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Callan Family Office, LLC's Holding History (CIK: 0001938970)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 14,440 Value ($000) $6,547 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 11,205 Value ($000) $4,388 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 16,715 Value ($000) $7,441 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 5,517 Value ($000) $2,675 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 2,450 Value ($000) $987 Avg Close $463.53 Range $377.85 - $519.88

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	14,440	$6,547	$431.03	$392.50 - $464.44
Q3 2025	11,205	$4,388	$417.92	$362.50 - $484.56
Q2 2025	16,715	$7,441	$460.83	$416.60 - $510.77
Q1 2025	5,517	$2,675	$466.00	$397.25 - $519.68
Q4 2024	2,450	$987	$463.53	$377.85 - $519.88