VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Rakuten Investment Management, Inc.'s Holding History (CIK: 0002062680)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 47,185 Value ($000) $21,695 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 242,462 Value ($000) $24,142 Avg Close $417.92 Range $362.50 - $484.56

Q1 2025

Shares 32,871 Value ($000) $16,195 Avg Close $466.00 Range $397.25 - $519.68

Q3 2024

Shares 20,495 Value ($000) $9,487 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 15,228 Value ($000) $7,195 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 9,407 Value ($000) $3,932 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 637 Value ($000) $261 Avg Close $369.42 Range $341.85 - $413.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	47,185	$21,695	$431.03	$392.50 - $464.44
Q3 2025	242,462	$24,142	$417.92	$362.50 - $484.56
Q1 2025	32,871	$16,195	$466.00	$397.25 - $519.68
Q3 2024	20,495	$9,487	$480.37	$456.07 - $510.64
Q2 2024	15,228	$7,195	$434.05	$391.01 - $486.43
Q1 2024	9,407	$3,932	$422.74	$403.43 - $448.40
Q4 2023	637	$261	$369.42	$341.85 - $413.00