| ORBIMED ADVISORS LLC | 3,060,000 | $2,025 |
| TCG Crossover Management, LLC | 2,676,580 | $1,772 |
| VANGUARD GROUP INC | 1,824,738 | $1,208 |
| ADAR1 Capital Management, LLC | 623,575 | $413 |
| STEMPOINT CAPITAL LP | 616,749 | $142 |
| JANE STREET GROUP, LLC | 527,127 | $349 |
| Ikarian Capital, LLC | 519,077 | $344 |
| BlackRock, Inc. | 422,759 | $280 |
| GEODE CAPITAL MANAGEMENT, LLC | 352,836 | $234 |
| LUMINUS MANAGEMENT LLC | 350,000 | $232 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 334,786 | $222 |
| AdvisorShares Investments LLC | 250,188 | $166 |
| MILLENNIUM MANAGEMENT LLC | 197,045 | $130 |
| TWO SIGMA INVESTMENTS, LP | 195,570 | $129 |
| RENAISSANCE TECHNOLOGIES LLC | 160,791 | $106 |
| DIMENSIONAL FUND ADVISORS LP | 151,874 | $101 |
| TWO SIGMA ADVISERS, LP | 137,732 | $91 |
| BOOTHBAY FUND MANAGEMENT, LLC | 134,571 | $89 |
| STATE STREET CORP | 121,114 | $80 |
| GROUP ONE TRADING, L.P. | 106,137 | $70 |
| OMERS ADMINISTRATION Corp | 103,400 | $68 |
| DIADEMA PARTNERS LP | 100,000 | $66 |
| TUDOR INVESTMENT CORP ET AL | 76,172 | $50 |
| NORTHERN TRUST CORP | 72,655 | $48 |
| Seven Fleet Capital Management LP | 62,701 | $42 |
| Qube Research & Technologies Ltd | 60,139 | $40 |
| OCCUDO QUANTITATIVE STRATEGIES LP | 59,038 | $39 |
| UBS Group AG | 51,993 | $34 |
| AMERICAN CENTURY COMPANIES INC | 48,770 | $32 |
| Virtu Financial LLC | 37,739 | $0 |
| HRT FINANCIAL LP | 37,585 | $0 |
| Engineers Gate Manager LP | 30,490 | $20 |
| Persistent Asset Partners Ltd | 26,612 | $18 |
| Kestra Advisory Services, LLC | 26,033 | $17 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 23,302 | $15 |
| Schonfeld Strategic Advisors LLC | 21,736 | $14 |
| HighTower Advisors, LLC | 20,628 | $14 |
| Lighthouse Investment Partners, LLC | 20,580 | $14 |
| MARSHALL WACE, LLP | 19,973 | $13 |
| Truvestments Capital LLC | 16,992 | $11 |
| Caption Management, LLC | 16,770 | $11 |
| StoneX Group Inc. | 13,349 | $9 |
| MORGAN STANLEY | 12,658 | $8 |
| DRW Securities, LLC | 10,000 | $7 |
| Tower Research Capital LLC (TRC) | 8,564 | $6 |
| OSAIC HOLDINGS, INC. | 5,269 | $3 |
| BANK OF AMERICA CORP /DE/ | 3,145 | $2 |
| Performa Ltd (US), LLC | 1,000 | $1 |
| CWM, LLC | 582 | $0 |
| MAI Capital Management | 526 | $0 |
| SBI Securities Co., Ltd. | 288 | $0 |
| JONES FINANCIAL COMPANIES LLLP | 114 | $0 |
| Fairman Group, LLC | 29 | $0 |
| JPMORGAN CHASE & CO | 16 | $0 |
| BNP PARIBAS ARBITRAGE, SA | 13 | $0 |