| RA CAPITAL MANAGEMENT, L.P. | 5,404,998 | $70,697 |
| FCPM III SERVICES B.V. | 3,617,354 | $47,315 |
| Frazier Life Sciences Management, L.P. | 2,543,939 | $33,275 |
| FMR LLC | 2,526,170 | $33,042 |
| VR Adviser, LLC | 1,943,766 | $25,424 |
| Paradigm Biocapital Advisors LP | 1,750,000 | $22,890 |
| GREAT POINT PARTNERS LLC | 1,370,107 | $17,921 |
| NEXTBio Capital Management LP | 999,967 | $13,080 |
| Caligan Partners LP | 925,067 | $9,963 |
| VANGUARD GROUP INC | 770,250 | $10,075 |
| BlackRock, Inc. | 465,636 | $6,091 |
| CITADEL ADVISORS LLC | 433,894 | $5,675 |
| SPHERA FUNDS MANAGEMENT LTD. | 410,417 | $5,368 |
| Laurion Capital Management LP | 317,243 | $4,150 |
| UBS Group AG | 292,118 | $3,821 |
| FINDELL CAPITAL MANAGEMENT LLC | 231,000 | $3,021 |
| MILLENNIUM MANAGEMENT LLC | 224,534 | $2,937 |
| GEODE CAPITAL MANAGEMENT, LLC | 185,808 | $2,432 |
| TUDOR INVESTMENT CORP ET AL | 167,673 | $2,193 |
| AMERIPRISE FINANCIAL INC | 163,061 | $2,133 |
| GOLDMAN SACHS GROUP INC | 145,640 | $1,905 |
| Logos Global Management LP | 100,000 | $1,308 |
| JANE STREET GROUP, LLC | 91,810 | $1,201 |
| STATE STREET CORP | 91,053 | $1,191 |
| JOHNSON & JOHNSON | 53,732 | $703 |
| NORTHERN TRUST CORP | 38,946 | $509 |
| MORGAN STANLEY | 28,463 | $372 |
| Engineers Gate Manager LP | 28,204 | $369 |
| Quadrature Capital Ltd | 26,791 | $350 |
| Sarissa Capital Management LP | 25,399 | $332 |
| Bollard Group LLC | 23,987 | $0 |
| OMERS ADMINISTRATION Corp | 20,700 | $271 |
| Squarepoint Ops LLC | 18,459 | $241 |
| XTX Topco Ltd | 17,542 | $229 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,819 | $194 |
| Persistent Asset Partners Ltd | 10,798 | $141 |
| Shay Capital LLC | 10,745 | $141 |
| Susquehanna Portfolio Strategies, LLC | 10,207 | $134 |
| Chung Wu Investment Group, LLC | 8,300 | $109 |
| CITIGROUP INC | 6,340 | $83 |
| Hudson Bay Capital Management LP | 5,110 | $67 |
| China Universal Asset Management Co., Ltd. | 2,746 | $36 |
| JPMORGAN CHASE & CO | 2,312 | $30 |
| Tower Research Capital LLC (TRC) | 1,729 | $23 |
| BARCLAYS PLC | 1,399 | $18 |
| Mirae Asset Global Investments Co., Ltd. | 819 | $11 |
| BANK OF AMERICA CORP /DE/ | 396 | $5 |
| GF FUND MANAGEMENT CO. LTD. | 330 | $4 |
| BNP PARIBAS ARBITRAGE, SA | 291 | $4 |
| MAI Capital Management | 40 | $1 |
| ROYAL BANK OF CANADA | 7 | $0 |
| Allworth Financial LP | 3 | $0 |
| SBI Securities Co., Ltd. | 3 | $0 |
| WELLS FARGO & COMPANY/MN | 1 | $0 |