| RA CAPITAL MANAGEMENT, L.P. | 6,681,307 | $4,233 |
| VANGUARD GROUP INC | 1,408,047 | $893 |
| MPM BioImpact LLC | 1,393,557 | $884 |
| BANK OF AMERICA CORP /DE/ | 737,550 | $467 |
| RENAISSANCE TECHNOLOGIES LLC | 677,766 | $429 |
| Lynx1 Capital Management LP | 655,926 | $416 |
| SPHERA FUNDS MANAGEMENT LTD. | 626,810 | $397 |
| DC Funds, LP | 589,102 | $373 |
| GEODE CAPITAL MANAGEMENT, LLC | 335,886 | $213 |
| MILLENNIUM MANAGEMENT LLC | 240,109 | $152 |
| Alyeska Investment Group, L.P. | 235,705 | $149 |
| JANE STREET GROUP, LLC | 157,322 | $100 |
| STATE STREET CORP | 119,168 | $75 |
| BlackRock, Inc. | 101,643 | $64 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,829 | $63 |
| NORTHERN TRUST CORP | 86,851 | $55 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 77,000 | $49 |
| UBS Group AG | 60,708 | $38 |
| Vontobel Holding Ltd. | 60,003 | $38 |
| Regal Investment Advisors LLC | 52,593 | $33 |
| EDGEWOOD MANAGEMENT LLC | 50,000 | $32 |
| MORGAN STANLEY | 46,002 | $29 |
| GOLDMAN SACHS GROUP INC | 34,073 | $22 |
| SIMPLEX TRADING, LLC | 24,054 | $15 |
| CERTUITY, LLC | 15,000 | $10 |
| Delta Investment Management, LLC | 14,925 | $9 |
| Point72 Asset Management, L.P. | 14,483 | $9 |
| BARCLAYS PLC | 13,236 | $8 |
| HBK Sorce Advisory LLC | 13,227 | $8 |
| Larson Financial Group LLC | 13,052 | $8 |
| Engineers Gate Manager LP | 12,185 | $8 |
| Ranch Capital Advisors Inc. | 12,000 | $8 |
| HIGHLINE WEALTH PARTNERS LLC | 12,000 | $8 |
| StoneX Group Inc. | 10,511 | $7 |
| TWO SIGMA ADVISERS, LP | 10,300 | $7 |
| Cetera Investment Advisers | 10,200 | $6 |
| OSAIC HOLDINGS, INC. | 8,625 | $5 |
| Financial Perspectives, Inc | 6,750 | $4 |
| TFC Financial Management, Inc. | 4,500 | $3 |
| FEDERATED HERMES, INC. | 4,387 | $3 |
| FMR LLC | 3,631 | $2 |
| JPMORGAN CHASE & CO | 2,072 | $1 |
| GROUP ONE TRADING, L.P. | 1,871 | $1 |
| BNP PARIBAS ARBITRAGE, SA | 792 | $1 |
| NISA INVESTMENT ADVISORS, LLC | 345 | $0 |
| ROYAL BANK OF CANADA | 62 | $0 |
| SBI Securities Co., Ltd. | 40 | $0 |
| SRS Capital Advisors, Inc. | 39 | $0 |
| Optiver Holding B.V. | 22 | $0 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 4 | $0 |
| CITIGROUP INC | 1 | $0 |