XENON PHARMACEUTICALS INC

Ticker: XENE CUSIP: 98420N105 Class: Common Stock

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 32,622 Value ($000) $1,454 Avg Close $42.00 Range $37.23 - $46.60

Q3 2025

Shares 23,932 Value ($000) $961 Avg Close $35.22 Range $30.00 - $40.35

Q2 2025

Shares 26,079 Value ($000) $816 Avg Close $32.62 Range $26.74 - $39.01

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	32,622	$1,454	$42.00	$37.23 - $46.60
Q3 2025	23,932	$961	$35.22	$30.00 - $40.35
Q2 2025	26,079	$816	$32.62	$26.74 - $39.01