| FMR LLC | 8,920,250 | $399,806 |
| Avoro Capital Advisors LLC | 5,424,444 | $243,124 |
| BlackRock, Inc. | 5,100,284 | $228,595 |
| WELLINGTON MANAGEMENT GROUP LLP | 4,764,779 | $213,557 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,538,691 | $203,424 |
| JANUS HENDERSON GROUP PLC | 4,084,034 | $183,110 |
| Capital International Investors | 3,414,959 | $153,058 |
| Polar Capital Holdings Plc | 2,465,694 | $110,512 |
| BRAIDWELL LP | 1,825,076 | $81,800 |
| Commodore Capital LP | 1,800,000 | $80,676 |
| ALLIANCEBERNSTEIN L.P. | 1,593,814 | $71,435 |
| JPMORGAN CHASE & CO | 1,494,032 | $66,963 |
| STATE STREET CORP | 1,492,550 | $66,896 |
| CITADEL ADVISORS LLC | 1,321,213 | $59,217 |
| JENNISON ASSOCIATES LLC | 1,292,055 | $57,910 |
| Holocene Advisors, LP | 1,282,081 | $57,463 |
| Affinity Asset Advisors, LLC | 1,250,000 | $56,025 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,226,771 | $54,984 |
| BNP Paribas Investment Partners S.A. | 1,060,221 | $48 |
| GEODE CAPITAL MANAGEMENT, LLC | 952,679 | $42,692 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 862,300 | $39 |
| Siren, L.L.C. | 812,761 | $36,428 |
| First Turn Management, LLC | 799,743 | $35,844 |
| Rock Springs Capital Management LP | 787,788 | $35,309 |
| FRANKLIN RESOURCES INC | 758,059 | $33,976 |
| abrdn plc | 750,291 | $33,628 |
| GOLDMAN SACHS GROUP INC | 696,047 | $31,197 |
| Fiera Capital Corp | 686,056 | $30,749 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 685,100 | $30,706 |
| AMERICAN CENTURY COMPANIES INC | 680,473 | $30,499 |
| FEDERATED HERMES, INC. | 672,237 | $30,130 |
| VANGUARD GROUP INC | 664,641 | $29,789 |
| Capital World Investors | 655,737 | $29,390 |
| MILLENNIUM MANAGEMENT LLC | 635,056 | $28,463 |
| Pictet Asset Management Holding SA | 625,985 | $28,010 |
| LOOMIS SAYLES & CO L P | 612,032 | $27,431 |
| BARCLAYS PLC | 600,964 | $26,935 |
| Vestal Point Capital, LP | 600,000 | $26,892 |
| Trails Edge Capital Partners, LP | 597,092 | $26,762 |
| Caligan Partners LP | 549,665 | $24,636 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 542,020 | $24,293 |
| TimesSquare Capital Management, LLC | 532,740 | $23,877 |
| MPM BioImpact LLC | 485,620 | $21,765 |
| DIMENSIONAL FUND ADVISORS LP | 452,147 | $20,261 |
| ORBIMED ADVISORS LLC | 447,200 | $20,044 |
| NORTHERN TRUST CORP | 438,714 | $19,663 |
| TWO SIGMA INVESTMENTS, LP | 436,743 | $19,575 |
| Candriam S.C.A. | 417,402 | $18,709 |
| Bank of New York Mellon Corp | 387,158 | $17,352 |
| BAKER BROS. ADVISORS LP | 370,208 | $16,593 |
| Deep Track Capital, LP | 366,435 | $16,424 |
| STEMPOINT CAPITAL LP | 348,605 | $15,624 |
| MORGAN STANLEY | 294,332 | $13,192 |
| DAFNA Capital Management LLC | 287,939 | $12,905 |
| DnB Asset Management AS | 272,831 | $12,228 |
| TWO SIGMA ADVISERS, LP | 259,320 | $11,623 |
| TUDOR INVESTMENT CORP ET AL | 254,002 | $11,384 |
| Nicholas Investment Partners, LP | 242,989 | $10,891 |
| Iron Triangle Partners LP | 233,688 | $10,474 |
| Eversept Partners, LP | 231,380 | $10,370 |
| NAN FUNG TRINITY (HK) LTD | 226,965 | $10,173 |
| BANK OF AMERICA CORP /DE/ | 221,368 | $9,922 |
| Nuveen, LLC | 216,238 | $9,692 |
| STATE OF WISCONSIN INVESTMENT BOARD | 205,569 | $9,214 |
| ADAR1 Capital Management, LLC | 203,969 | $9,142 |
| PERCEPTIVE ADVISORS LLC | 200,791 | $8,999 |
| DEUTSCHE BANK AG\ | 190,233 | $8,526 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 189,059 | $8,474 |
| NEW YORK STATE COMMON RETIREMENT FUND | 186,705 | $8,368 |
| NEXTBio Capital Management LP | 183,704 | $8,234 |
| NEUBERGER BERMAN GROUP LLC | 178,747 | $8,011 |
| PEREGRINE CAPITAL MANAGEMENT LLC | 174,851 | $7,837 |
| Jain Global LLC | 173,882 | $7,793 |
| MARSHALL WACE, LLP | 162,551 | $7,286 |
| Foresite Capital Management IV, LLC | 160,000 | $7,171 |
| Parkman Healthcare Partners LLC | 154,184 | $6,911 |
| WELLS FARGO & COMPANY/MN | 152,297 | $6,826 |
| MOORE CAPITAL MANAGEMENT, LP | 140,000 | $6,275 |
| Rhenman & Partners Asset Management AB | 139,000 | $6,230 |
| Patient Square Capital LP | 136,500 | $6,118 |
| Redmile Group, LLC | 133,882 | $6,001 |
| ALGERT GLOBAL LLC | 123,189 | $6 |
| Assenagon Asset Management S.A. | 119,186 | $5,342 |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 116,088 | $5,203 |
| Man Group plc | 114,826 | $5,147 |
| Swiss National Bank | 114,000 | $5,109 |
| AMERIPRISE FINANCIAL INC | 109,544 | $4,910 |
| Squadron Capital Management LLC | 105,551 | $4,731 |
| Palo Alto Investors LP | 96,519 | $4,326 |
| Verition Fund Management LLC | 93,756 | $4,202 |
| BNP PARIBAS ARBITRAGE, SA | 93,462 | $4,189 |
| Granahan Investment Management, LLC | 92,778 | $4,158 |
| T. Rowe Price Investment Management, Inc. | 92,547 | $4 |
| Atika Capital Management LLC | 92,506 | $4,146 |
| RHUMBLINE ADVISERS | 90,143 | $4,040 |
| ROYAL BANK OF CANADA | 89,757 | $4,023 |
| Russell Investments Group, Ltd. | 86,220 | $3,864 |
| BALYASNY ASSET MANAGEMENT L.P. | 84,360 | $3,781 |
| RAYMOND JAMES FINANCIAL INC | 83,255 | $3,731 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 81,156 | $3,581 |
| 145 other institutions | 2,017,652 | $83,401 |