XENON PHARMACEUTICALS INC

Ticker: XENE CUSIP: 98420N105 Class: Common Stock

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 30,851 Value ($000) $1,383 Avg Close $42.00 Range $37.23 - $46.60

Q3 2025

Shares 48,455 Value ($000) $1,945 Avg Close $35.22 Range $30.00 - $40.35

Q2 2025

Shares 141,783 Value ($000) $4,438 Avg Close $32.62 Range $26.74 - $39.01

Q1 2025

Shares 152,188 Value ($000) $5,106 Avg Close $37.97 Range $32.70 - $42.23

Q4 2024

Shares 86,973 Value ($000) $3,409 Avg Close $41.35 Range $37.34 - $46.00

Q3 2024

Shares 204,892 Value ($000) $8,067 Avg Close $40.32 Range $35.73 - $44.74

Q2 2024

Shares 161,722 Value ($000) $6,306 Avg Close $39.97 Range $35.53 - $44.37

Q1 2024

Shares 198,526 Value ($000) $8,547 Avg Close $46.00 Range $42.08 - $50.99

Q4 2023

Shares 84,153 Value ($000) $3,876 Avg Close $35.33 Range $27.98 - $47.00

Q3 2023

Shares 40,547 Value ($000) $1,385 Avg Close $37.40 Range $33.93 - $40.13

Q2 2023

Shares 98,745 Value ($000) $3,802 Avg Close $39.75 Range $33.60 - $43.75

Q1 2023

Shares 206,672 Value ($000) $7,397 Avg Close $36.94 Range $32.64 - $41.25

Q4 2022

Shares 360,421 Value ($000) $14,211 Avg Close $36.42 Range $31.79 - $40.06

Q3 2022

Shares 409,563 Value ($000) $14,785 Avg Close $35.95 Range $28.98 - $41.39

Q2 2022

Shares 326,542 Value ($000) $9,933 Avg Close $30.24 Range $24.94 - $35.69

Q1 2022

Shares 330,527 Value ($000) $10,104 Avg Close $29.94 Range $24.60 - $33.45

Q4 2021

Shares 475,140 Value ($000) $14,843 Avg Close $29.88 Range $15.29 - $36.42

Q3 2021

Shares 148,879 Value ($000) $2,275 Avg Close $17.38 Range $14.65 - $19.64

Q2 2021

Shares 164,071 Value ($000) $3,055 Avg Close $18.43 Range $16.30 - $21.52

Q1 2021

Shares 174,995 Value ($000) $3,133 Avg Close $16.95 Range $13.23 - $21.94

Q4 2020

Shares 183,740 Value ($000) $2,826 Avg Close $11.70 Range $9.32 - $16.41

Q3 2020

Shares 192,313 Value ($000) $2,129 Avg Close $11.77 Range $10.11 - $14.10

Q2 2020

Shares 209,618 Value ($000) $2,629 Avg Close $12.73 Range $9.96 - $17.00

Q1 2020

Shares 142,508 Value ($000) $1,616 Avg Close $14.24 Range $7.00 - $18.45

Q4 2019

Shares 46,877 Value ($000) $615 Avg Close $10.52 Range $7.88 - $14.95

Q3 2019

Shares 30,898 Value ($000) $278 Avg Close $9.46 Range $8.54 - $10.90

Q2 2019

Shares 30,766 Value ($000) $303 Avg Close $9.57 Range $8.22 - $11.34

Q1 2019

Shares 55,632 Value ($000) $565 Avg Close $8.48 Range $6.17 - $10.74

Q4 2018

Shares 131,220 Value ($000) $828 Avg Close $8.89 Range $5.41 - $13.49

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	30,851	$1,383	$42.00	$37.23 - $46.60
Q3 2025	48,455	$1,945	$35.22	$30.00 - $40.35
Q2 2025	141,783	$4,438	$32.62	$26.74 - $39.01
Q1 2025	152,188	$5,106	$37.97	$32.70 - $42.23
Q4 2024	86,973	$3,409	$41.35	$37.34 - $46.00
Q3 2024	204,892	$8,067	$40.32	$35.73 - $44.74
Q2 2024	161,722	$6,306	$39.97	$35.53 - $44.37
Q1 2024	198,526	$8,547	$46.00	$42.08 - $50.99
Q4 2023	84,153	$3,876	$35.33	$27.98 - $47.00
Q3 2023	40,547	$1,385	$37.40	$33.93 - $40.13
Q2 2023	98,745	$3,802	$39.75	$33.60 - $43.75
Q1 2023	206,672	$7,397	$36.94	$32.64 - $41.25
Q4 2022	360,421	$14,211	$36.42	$31.79 - $40.06
Q3 2022	409,563	$14,785	$35.95	$28.98 - $41.39
Q2 2022	326,542	$9,933	$30.24	$24.94 - $35.69
Q1 2022	330,527	$10,104	$29.94	$24.60 - $33.45
Q4 2021	475,140	$14,843	$29.88	$15.29 - $36.42
Q3 2021	148,879	$2,275	$17.38	$14.65 - $19.64
Q2 2021	164,071	$3,055	$18.43	$16.30 - $21.52
Q1 2021	174,995	$3,133	$16.95	$13.23 - $21.94
Q4 2020	183,740	$2,826	$11.70	$9.32 - $16.41
Q3 2020	192,313	$2,129	$11.77	$10.11 - $14.10
Q2 2020	209,618	$2,629	$12.73	$9.96 - $17.00
Q1 2020	142,508	$1,616	$14.24	$7.00 - $18.45
Q4 2019	46,877	$615	$10.52	$7.88 - $14.95
Q3 2019	30,898	$278	$9.46	$8.54 - $10.90
Q2 2019	30,766	$303	$9.57	$8.22 - $11.34
Q1 2019	55,632	$565	$8.48	$6.17 - $10.74
Q4 2018	131,220	$828	$8.89	$5.41 - $13.49