XENON PHARMACEUTICALS INC

Ticker: XENE CUSIP: 98420N105 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 436,743 Value ($000) $19,575 Avg Close $42.00 Range $37.23 - $46.60

Q1 2025

Shares 236,983 Value ($000) $7,951 Avg Close $37.97 Range $32.70 - $42.23

Q4 2024

Shares 273,352 Value ($000) $10,715 Avg Close $41.35 Range $37.34 - $46.00

Q3 2024

Shares 243,579 Value ($000) $9,590 Avg Close $40.32 Range $35.73 - $44.74

Q2 2024

Shares 195,129 Value ($000) $7,608 Avg Close $39.97 Range $35.53 - $44.37

Q1 2024

Shares 274,626 Value ($000) $11,823 Avg Close $46.00 Range $42.08 - $50.99

Q4 2023

Shares 340,015 Value ($000) $15,661 Avg Close $35.33 Range $27.98 - $47.00

Q3 2023

Shares 80,633 Value ($000) $2,754 Avg Close $37.40 Range $33.93 - $40.13

Q2 2023

Shares 18,633 Value ($000) $717 Avg Close $39.75 Range $33.60 - $43.75

Q1 2023

Shares 11,454 Value ($000) $410 Avg Close $36.94 Range $32.64 - $41.25

Q3 2022

Shares 55,974 Value ($000) $2,021 Avg Close $35.95 Range $28.98 - $41.39

Q1 2022

Shares 232,650 Value ($000) $7,112 Avg Close $29.94 Range $24.60 - $33.45

Q4 2021

Shares 278,343 Value ($000) $8,695 Avg Close $29.88 Range $15.29 - $36.42

Q3 2021

Shares 169,676 Value ($000) $2,593 Avg Close $17.38 Range $14.65 - $19.64

Q2 2021

Shares 85,218 Value ($000) $1,587 Avg Close $18.43 Range $16.30 - $21.52

Q1 2021

Shares 76,706 Value ($000) $1,373 Avg Close $16.95 Range $13.23 - $21.94

Q4 2020

Shares 50,561 Value ($000) $778 Avg Close $11.70 Range $9.32 - $16.41

Q3 2020

Shares 49,985 Value ($000) $553 Avg Close $11.77 Range $10.11 - $14.10

Q2 2020

Shares 120,115 Value ($000) $1,506 Avg Close $12.73 Range $9.96 - $17.00

Q1 2020

Shares 88,605 Value ($000) $1,005 Avg Close $14.24 Range $7.00 - $18.45

Q4 2019

Shares 76,817 Value ($000) $1,007 Avg Close $10.52 Range $7.88 - $14.95

Q1 2019

Shares 58,149 Value ($000) $591 Avg Close $8.48 Range $6.17 - $10.74

Q4 2018

Shares 200,261 Value ($000) $1,264 Avg Close $8.89 Range $5.41 - $13.49

Q3 2018

Shares 76,585 Value ($000) $1,011 Avg Close $11.59 Range $8.85 - $15.92

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	436,743	$19,575	$42.00	$37.23 - $46.60
Q1 2025	236,983	$7,951	$37.97	$32.70 - $42.23
Q4 2024	273,352	$10,715	$41.35	$37.34 - $46.00
Q3 2024	243,579	$9,590	$40.32	$35.73 - $44.74
Q2 2024	195,129	$7,608	$39.97	$35.53 - $44.37
Q1 2024	274,626	$11,823	$46.00	$42.08 - $50.99
Q4 2023	340,015	$15,661	$35.33	$27.98 - $47.00
Q3 2023	80,633	$2,754	$37.40	$33.93 - $40.13
Q2 2023	18,633	$717	$39.75	$33.60 - $43.75
Q1 2023	11,454	$410	$36.94	$32.64 - $41.25
Q3 2022	55,974	$2,021	$35.95	$28.98 - $41.39
Q1 2022	232,650	$7,112	$29.94	$24.60 - $33.45
Q4 2021	278,343	$8,695	$29.88	$15.29 - $36.42
Q3 2021	169,676	$2,593	$17.38	$14.65 - $19.64
Q2 2021	85,218	$1,587	$18.43	$16.30 - $21.52
Q1 2021	76,706	$1,373	$16.95	$13.23 - $21.94
Q4 2020	50,561	$778	$11.70	$9.32 - $16.41
Q3 2020	49,985	$553	$11.77	$10.11 - $14.10
Q2 2020	120,115	$1,506	$12.73	$9.96 - $17.00
Q1 2020	88,605	$1,005	$14.24	$7.00 - $18.45
Q4 2019	76,817	$1,007	$10.52	$7.88 - $14.95
Q1 2019	58,149	$591	$8.48	$6.17 - $10.74
Q4 2018	200,261	$1,264	$8.89	$5.41 - $13.49
Q3 2018	76,585	$1,011	$11.59	$8.85 - $15.92