XENON PHARMACEUTICALS INC

Ticker: XENE CUSIP: 98420N105 Class: Common Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 259,320 Value ($000) $11,623 Avg Close $42.00 Range $37.23 - $46.60

Q3 2025

Shares 18,100 Value ($000) $727 Avg Close $35.22 Range $30.00 - $40.35

Q2 2025

Shares 95,300 Value ($000) $2,983 Avg Close $32.62 Range $26.74 - $39.01

Q1 2025

Shares 298,800 Value ($000) $10,025 Avg Close $37.97 Range $32.70 - $42.23

Q4 2024

Shares 298,700 Value ($000) $11,709 Avg Close $41.35 Range $37.34 - $46.00

Q3 2024

Shares 273,700 Value ($000) $10,776 Avg Close $40.32 Range $35.73 - $44.74

Q2 2024

Shares 208,900 Value ($000) $8,145 Avg Close $39.97 Range $35.53 - $44.37

Q1 2024

Shares 229,200 Value ($000) $9,867 Avg Close $46.00 Range $42.08 - $50.99

Q4 2023

Shares 252,700 Value ($000) $11,639 Avg Close $35.33 Range $27.98 - $47.00

Q3 2023

Shares 64,900 Value ($000) $2,217 Avg Close $37.40 Range $33.93 - $40.13

Q4 2022

Shares 22,700 Value ($000) $895 Avg Close $36.42 Range $31.79 - $40.06

Q3 2022

Shares 91,000 Value ($000) $3,285 Avg Close $35.95 Range $28.98 - $41.39

Q2 2022

Shares 52,300 Value ($000) $1,591 Avg Close $30.24 Range $24.94 - $35.69

Q1 2022

Shares 122,700 Value ($000) $3,751 Avg Close $29.94 Range $24.60 - $33.45

Q4 2021

Shares 126,600 Value ($000) $3,955 Avg Close $29.88 Range $15.29 - $36.42

Q3 2021

Shares 175,800 Value ($000) $2,686 Avg Close $17.38 Range $14.65 - $19.64

Q2 2021

Shares 83,000 Value ($000) $1,545 Avg Close $18.43 Range $16.30 - $21.52

Q1 2021

Shares 88,900 Value ($000) $1,591 Avg Close $16.95 Range $13.23 - $21.94

Q4 2020

Shares 98,500 Value ($000) $1,515 Avg Close $11.70 Range $9.32 - $16.41

Q3 2020

Shares 105,700 Value ($000) $1,170 Avg Close $11.77 Range $10.11 - $14.10

Q2 2020

Shares 100,900 Value ($000) $1,265 Avg Close $12.73 Range $9.96 - $17.00

Q1 2020

Shares 63,500 Value ($000) $720 Avg Close $14.24 Range $7.00 - $18.45

Q4 2019

Shares 33,100 Value ($000) $434 Avg Close $10.52 Range $7.88 - $14.95

Q3 2019

Shares 26,900 Value ($000) $242 Avg Close $9.46 Range $8.54 - $10.90

Q2 2019

Shares 32,600 Value ($000) $321 Avg Close $9.57 Range $8.22 - $11.34

Q1 2019

Shares 37,100 Value ($000) $377 Avg Close $8.48 Range $6.17 - $10.74

Q4 2018

Shares 36,200 Value ($000) $228 Avg Close $8.89 Range $5.41 - $13.49

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	259,320	$11,623	$42.00	$37.23 - $46.60
Q3 2025	18,100	$727	$35.22	$30.00 - $40.35
Q2 2025	95,300	$2,983	$32.62	$26.74 - $39.01
Q1 2025	298,800	$10,025	$37.97	$32.70 - $42.23
Q4 2024	298,700	$11,709	$41.35	$37.34 - $46.00
Q3 2024	273,700	$10,776	$40.32	$35.73 - $44.74
Q2 2024	208,900	$8,145	$39.97	$35.53 - $44.37
Q1 2024	229,200	$9,867	$46.00	$42.08 - $50.99
Q4 2023	252,700	$11,639	$35.33	$27.98 - $47.00
Q3 2023	64,900	$2,217	$37.40	$33.93 - $40.13
Q4 2022	22,700	$895	$36.42	$31.79 - $40.06
Q3 2022	91,000	$3,285	$35.95	$28.98 - $41.39
Q2 2022	52,300	$1,591	$30.24	$24.94 - $35.69
Q1 2022	122,700	$3,751	$29.94	$24.60 - $33.45
Q4 2021	126,600	$3,955	$29.88	$15.29 - $36.42
Q3 2021	175,800	$2,686	$17.38	$14.65 - $19.64
Q2 2021	83,000	$1,545	$18.43	$16.30 - $21.52
Q1 2021	88,900	$1,591	$16.95	$13.23 - $21.94
Q4 2020	98,500	$1,515	$11.70	$9.32 - $16.41
Q3 2020	105,700	$1,170	$11.77	$10.11 - $14.10
Q2 2020	100,900	$1,265	$12.73	$9.96 - $17.00
Q1 2020	63,500	$720	$14.24	$7.00 - $18.45
Q4 2019	33,100	$434	$10.52	$7.88 - $14.95
Q3 2019	26,900	$242	$9.46	$8.54 - $10.90
Q2 2019	32,600	$321	$9.57	$8.22 - $11.34
Q1 2019	37,100	$377	$8.48	$6.17 - $10.74
Q4 2018	36,200	$228	$8.89	$5.41 - $13.49