XORTX THERAPEUTICS INC

Ticker: XRTX CUSIP: 98420Q306 Class: COM

Holders for Q4 2025 Position Changes for Q4 2025

Note: Option positions (PUT/CALL) are excluded.

New Positions (3)

DRW Securities, LLC

Value ($000) $109 Shares 193,599

TWO SIGMA SECURITIES, LLC

Value ($000) $7 Shares 12,597

Baader Bank Aktiengesellschaft

Value ($000) $5 Shares 18,732

Institution	Shares	Value ($000)
DRW Securities, LLC	193,599	$109
TWO SIGMA SECURITIES, LLC	12,597	$7
Baader Bank Aktiengesellschaft	18,732	$5

Increased Positions (2)

ROYAL BANK OF CANADA

Value ($000) $2 Shares 4,091 (+1042.7%)

Value ($000) $1 (+314.2%) Shares 1,401 (+498.7%)

Institution	Prev Shares	Curr Shares	Change
ROYAL BANK OF CANADA	358	4,091	+3,733 (+1042.7%)
UBS Group AG	234	1,401	+1,167 (+498.7%)

Exited Positions (3)

CITADEL ADVISORS LLC

Value ($000) $70 Shares 86,326

Value ($000) $11 Shares 13,820

SBI Securities Co., Ltd.

Value ($000) $0 Shares 1

Institution	Prev Shares	Prev Value ($000)
CITADEL ADVISORS LLC	86,326	$70
XTX Topco Ltd	13,820	$11
SBI Securities Co., Ltd.	1	$0