| Empery Asset Management, LP | 8,951,105 | $35,804 |
| FMR LLC | 8,499,100 | $33,996 |
| MORGAN STANLEY | 8,208,015 | $32,832 |
| Bain Capital Life Sciences Investors, LLC | 7,967,454 | $31,870 |
| PERCEPTIVE ADVISORS LLC | 6,314,452 | $25,258 |
| Saturn V Capital Management LP | 5,800,530 | $23,202 |
| Deep Track Capital, LP | 5,013,661 | $20,055 |
| Kalehua Capital Management LLC | 3,722,840 | $14,891 |
| VANGUARD GROUP INC | 3,423,662 | $13,695 |
| BRAIDWELL LP | 3,368,904 | $13,476 |
| Blackstone Inc. | 2,681,922 | $10,728 |
| Rosalind Advisors, Inc. | 2,605,920 | $10,424 |
| Trails Edge Capital Partners, LP | 2,571,478 | $10,286 |
| Nantahala Capital Management, LLC | 2,449,468 | $9,798 |
| BVF INC/IL | 2,233,742 | $8,935 |
| Samsara BioCapital, LLC | 1,960,000 | $7,840 |
| Siren, L.L.C. | 1,500,000 | $6,000 |
| BlackRock, Inc. | 1,226,808 | $4,907 |
| Woodline Partners LP | 1,000,855 | $4,003 |
| GEODE CAPITAL MANAGEMENT, LLC | 940,447 | $3,764 |
| STEMPOINT CAPITAL LP | 898,465 | $3,594 |
| GOLDMAN SACHS GROUP INC | 831,890 | $3,328 |
| Point72 Asset Management, L.P. | 808,154 | $3,233 |
| Stonepine Capital Management, LLC | 593,573 | $2,374 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 357,387 | $1,430 |
| STATE STREET CORP | 198,234 | $793 |
| NORTHERN TRUST CORP | 178,235 | $713 |
| Pale Fire Capital SE | 167,590 | $670 |
| Affinity Asset Advisors, LLC | 145,000 | $580 |
| CITADEL ADVISORS LLC | 128,675 | $515 |
| Palumbo Wealth Management LLC | 113,357 | $453 |
| OMERS ADMINISTRATION Corp | 109,200 | $437 |
| JANE STREET GROUP, LLC | 91,413 | $366 |
| MARSHALL WACE, LLP | 80,456 | $322 |
| ExodusPoint Capital Management, LP | 79,072 | $316 |
| Qube Research & Technologies Ltd | 67,747 | $271 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 66,788 | $267 |
| BALYASNY ASSET MANAGEMENT L.P. | 64,505 | $258 |
| BARCLAYS PLC | 57,500 | $230 |
| MILLENNIUM MANAGEMENT LLC | 55,978 | $224 |
| Susquehanna Portfolio Strategies, LLC | 43,259 | $173 |
| BANK OF AMERICA CORP /DE/ | 35,761 | $143 |
| CITIGROUP INC | 32,332 | $129 |
| Hudson Bay Capital Management LP | 32,239 | $129 |
| Jefferies Financial Group Inc. | 26,118 | $104 |
| Man Group plc | 24,187 | $97 |
| Virtu Financial LLC | 22,489 | $0 |
| Lighthouse Investment Partners, LLC | 22,200 | $89 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22,135 | $89 |
| STIFEL FINANCIAL CORP | 20,496 | $82 |
| TWO SIGMA INVESTMENTS, LP | 17,246 | $69 |
| Creative Planning | 16,427 | $66 |
| CAXTON CORP | 15,557 | $62 |
| Squarepoint Ops LLC | 12,518 | $50 |
| Tower Research Capital LLC (TRC) | 10,446 | $42 |
| Indivisible Partners | 10,000 | $40 |
| JPMORGAN CHASE & CO | 4,581 | $18 |
| UBS Group AG | 4,129 | $17 |
| GROUP ONE TRADING, L.P. | 3,998 | $16 |
| SIGNATUREFD, LLC | 2,754 | $11 |
| CIBC Private Wealth Group, LLC | 2,166 | $9 |
| PNC Financial Services Group, Inc. | 1,759 | $7 |
| Russell Investments Group, Ltd. | 729 | $3 |
| Allworth Financial LP | 715 | $3 |
| Bleichroeder LP | 595 | $2 |
| BNP PARIBAS ARBITRAGE, SA | 511 | $2 |
| Farther Finance Advisors, LLC | 331 | $1 |
| Ronald Blue Trust, Inc. | 284 | $1 |
| Fortitude Family Office, LLC | 137 | $1 |
| ROYAL BANK OF CANADA | 104 | $0 |
| SBI Securities Co., Ltd. | 50 | $0 |
| JONES FINANCIAL COMPANIES LLLP | 38 | $0 |
| NewEdge Advisors, LLC | 33 | $0 |
| Rockefeller Capital Management L.P. | 33 | $0 |
| HighMark Wealth Management LLC | 6 | $0 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 5 | $0 |