| RTW INVESTMENTS, LP | 6,959,032 | $122,757 |
| Frazier Life Sciences Management, L.P. | 1,902,320 | $33,557 |
| Clearbridge Investments, LLC | 1,808,035 | $31,894 |
| UBS Group AG | 1,782,252 | $31,439 |
| CITADEL ADVISORS LLC | 1,687,846 | $29,774 |
| FMR LLC | 1,440,406 | $25,409 |
| BAMCO INC /NY/ | 1,418,005 | $25,014 |
| ADAR1 Capital Management, LLC | 1,246,520 | $21,989 |
| Rock Springs Capital Management LP | 811,546 | $14,316 |
| WELLINGTON MANAGEMENT GROUP LLP | 752,858 | $13,280 |
| BlackRock, Inc. | 635,213 | $11,205 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 602,954 | $11 |
| C WorldWide Group Holding A/S | 510,000 | $9 |
| B Group, Inc. | 400,000 | $7,056 |
| BANK OF AMERICA CORP /DE/ | 388,769 | $6,858 |
| Legal & General Group Plc | 387,800 | $6,843 |
| JANE STREET GROUP, LLC | 382,062 | $6,740 |
| Walleye Capital LLC | 373,399 | $6,587 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 299,844 | $5,286 |
| JPMORGAN CHASE & CO | 293,703 | $5,181 |
| MORGAN STANLEY | 289,705 | $5,110 |
| NAN FUNG TRINITY (HK) LTD | 269,975 | $4,762 |
| D. E. Shaw & Co., Inc. | 238,609 | $4,209 |
| MARSHALL WACE, LLP | 231,802 | $4,089 |
| Hennion & Walsh Asset Management, Inc. | 204,982 | $3,616 |
| XY Capital Ltd | 202,304 | $3,569 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 196,853 | $3,472 |
| AMERIPRISE FINANCIAL INC | 181,133 | $3,195 |
| DIMENSIONAL FUND ADVISORS LP | 173,946 | $3,068 |
| Campbell & CO Investment Adviser LLC | 170,117 | $3,001 |
| NEXTBio Capital Management LP | 163,362 | $2,882 |
| ENVESTNET ASSET MANAGEMENT INC | 151,318 | $2,669 |
| GOLDMAN SACHS GROUP INC | 149,434 | $2,636 |
| STATE STREET CORP | 136,428 | $2,407 |
| Privium Fund Management B.V. | 132,189 | $2,332 |
| Qube Research & Technologies Ltd | 107,651 | $1,899 |
| Mirae Asset Global Investments Co., Ltd. | 103,118 | $1,819 |
| PRINCIPAL FINANCIAL GROUP INC | 101,782 | $1,795 |
| DCF Advisers, LLC | 97,500 | $1,720 |
| NORTHERN TRUST CORP | 96,442 | $1,701 |
| WELLS FARGO & COMPANY/MN | 93,140 | $1,643 |
| RAYMOND JAMES FINANCIAL INC | 92,837 | $1,638 |
| ALPS ADVISORS INC | 92,107 | $1,625 |
| Hudson Bay Capital Management LP | 90,000 | $1,588 |
| TD Asset Management Inc | 86,640 | $1,528 |
| HRT FINANCIAL LP | 83,793 | $1 |
| NEOS Investment Management LLC | 75,165 | $1,326 |
| BNP Paribas Investment Partners S.A. | 65,814 | $1 |
| Long Corridor Asset Management Ltd | 65,800 | $1,161 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,895 | $1,004 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 46,935 | $827 |
| Schonfeld Strategic Advisors LLC | 40,005 | $706 |
| Virtus Investment Advisers, LLC | 38,457 | $678 |
| WealthPlan Investment Management, LLC | 36,761 | $648 |
| DekaBank Deutsche Girozentrale | 36,648 | $1 |
| MML INVESTORS SERVICES, LLC | 34,421 | $607 |
| LPL Financial LLC | 31,114 | $549 |
| DRW Securities, LLC | 30,862 | $544 |
| Invesco Ltd. | 30,594 | $540 |
| TWO SIGMA INVESTMENTS, LP | 29,523 | $521 |
| GEODE CAPITAL MANAGEMENT, LLC | 23,879 | $421 |
| BANK OF MONTREAL /CAN/ | 22,099 | $390 |
| Brinker Capital Investments, LLC | 20,849 | $368 |
| GROUP ONE TRADING, L.P. | 19,032 | $336 |
| US BANCORP \DE\ | 17,771 | $313 |
| Marks Group Wealth Management, Inc | 16,278 | $287 |
| Legacy Wealth Asset Management, LLC | 15,903 | $281 |
| Headlands Technologies LLC | 15,846 | $280 |
| Erste Asset Management GmbH | 15,100 | $269 |
| IvyRock Asset Management (HK) Ltd | 14,979 | $264 |
| ROYAL BANK OF CANADA | 14,757 | $260 |
| ExodusPoint Capital Management, LP | 13,618 | $240 |
| Persistent Asset Partners Ltd | 12,339 | $218 |
| OPPENHEIMER ASSET MANAGEMENT INC. | 10,608 | $187 |
| Virtu Financial LLC | 10,551 | $0 |
| SG Americas Securities, LLC | 10,396 | $0 |
| LMR Partners LLP | 10,320 | $182 |
| Quantinno Capital Management LP | 10,085 | $178 |
| China Universal Asset Management Co., Ltd. | 6,380 | $113 |
| CITIGROUP INC | 5,151 | $91 |
| Farther Finance Advisors, LLC | 1,329 | $23 |
| CWM, LLC | 979 | $0 |
| BNP PARIBAS ARBITRAGE, SA | 884 | $16 |
| Tower Research Capital LLC (TRC) | 804 | $14 |
| GF FUND MANAGEMENT CO. LTD. | 768 | $14 |
| Horizon Investments, LLC | 735 | $13 |
| SRS Capital Advisors, Inc. | 409 | $7 |
| Smartleaf Asset Management LLC | 331 | $6 |
| Caitong International Asset Management Co., Ltd | 325 | $6 |
| OSAIC HOLDINGS, INC. | 319 | $6 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 317 | $6 |
| PNC Financial Services Group, Inc. | 302 | $5 |
| RHUMBLINE ADVISERS | 281 | $5 |
| ASSETMARK, INC | 233 | $4 |
| Quent Capital, LLC | 230 | $4 |
| Parkside Financial Bank & Trust | 213 | $4 |
| PRIVATE TRUST CO NA | 206 | $4 |
| EverSource Wealth Advisors, LLC | 203 | $4 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 202 | $4 |
| Pinnacle Wealth Planning Services, Inc. | 201 | $4 |
| 24 other institutions | 1,334 | $18 |