ZYMEWORKS INC

Ticker: ZYME CUSIP: 98985Y108 Class: Common Stock

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 663,546 Value ($000) $17,471 Avg Close $21.81 Range $16.00 - $28.49

Q3 2025

Shares 564,000 Value ($000) $9,633 Avg Close $14.31 Range $11.51 - $17.60

Q2 2025

Shares 476,000 Value ($000) $5,974 Avg Close $11.91 Range $9.03 - $13.44

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	663,546	$17,471	$21.81	$16.00 - $28.49
Q3 2025	564,000	$9,633	$14.31	$11.51 - $17.60
Q2 2025	476,000	$5,974	$11.91	$9.03 - $13.44