| EcoR1 Capital, LLC | 22,970,388 | $604,810 |
| Rubric Capital Management LP | 5,750,000 | $151,398 |
| BlackRock, Inc. | 4,595,548 | $121,001 |
| BVF INC/IL | 3,938,641 | $103,704 |
| PERCEPTIVE ADVISORS LLC | 3,261,850 | $85,885 |
| MORGAN STANLEY | 2,593,080 | $68,276 |
| VANGUARD GROUP INC | 2,328,727 | $61,315 |
| BNP Paribas Investment Partners S.A. | 1,822,048 | $48 |
| Siren, L.L.C. | 1,680,121 | $44,238 |
| DEUTSCHE BANK AG\ | 1,595,833 | $42,018 |
| DIMENSIONAL FUND ADVISORS LP | 1,159,215 | $30,523 |
| Nextech Invest, Ltd. | 1,113,946 | $29,330 |
| STATE STREET CORP | 1,037,642 | $27,321 |
| Capricorn Fund Managers Ltd | 1,022,840 | $26,931 |
| Vestal Point Capital, LP | 865,000 | $22,775 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 700,002 | $18,431 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 663,546 | $17,471 |
| Nuveen, LLC | 648,326 | $17,070 |
| GEODE CAPITAL MANAGEMENT, LLC | 647,970 | $17,060 |
| Assenagon Asset Management S.A. | 647,374 | $17,045 |
| FMR LLC | 560,086 | $14,747 |
| Prosight Management, LP | 530,393 | $13,965 |
| Redmile Group, LLC | 491,654 | $12,945 |
| Qube Research & Technologies Ltd | 474,290 | $12,488 |
| ALGERT GLOBAL LLC | 423,646 | $11 |
| GOLDMAN SACHS GROUP INC | 420,207 | $11,064 |
| MILLENNIUM MANAGEMENT LLC | 381,621 | $10,048 |
| UBS ASSET MANAGEMENT AMERICAS INC | 320,261 | $8,432 |
| NORTHERN TRUST CORP | 307,979 | $8,109 |
| Schonfeld Strategic Advisors LLC | 288,571 | $7,598 |
| UBS Group AG | 278,854 | $7,342 |
| Invesco Ltd. | 257,580 | $6,782 |
| CITADEL ADVISORS LLC | 255,351 | $6,723 |
| PICTON MAHONEY ASSET MANAGEMENT | 244,798 | $6,446 |
| Hillsdale Investment Management Inc. | 237,922 | $6,264 |
| Granahan Investment Management, LLC | 224,408 | $5,909 |
| SummitTX Capital, L.P. | 224,268 | $5,905 |
| D. E. Shaw & Co., Inc. | 223,786 | $5,892 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 220,909 | $5,817 |
| RENAISSANCE TECHNOLOGIES LLC | 220,877 | $5,816 |
| WELLS FARGO & COMPANY/MN | 208,313 | $5,485 |
| RAYMOND JAMES FINANCIAL INC | 187,685 | $4,942 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 181,790 | $4,787 |
| WELLINGTON MANAGEMENT GROUP LLP | 181,705 | $4,784 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 176,088 | $4,636 |
| FEDERATED HERMES, INC. | 152,689 | $4,020 |
| KENNEDY CAPITAL MANAGEMENT LLC | 145,534 | $3,832 |
| Bank of New York Mellon Corp | 128,131 | $3,374 |
| JUPITER ASSET MANAGEMENT LTD | 125,506 | $3,305 |
| HRT FINANCIAL LP | 121,064 | $3 |
| AMERIPRISE FINANCIAL INC | 113,141 | $2,979 |
| CITIGROUP INC | 111,207 | $2,928 |
| Opaleye Management Inc. | 108,929 | $2,868 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 105,184 | $2,769 |
| Trexquant Investment LP | 101,274 | $2,667 |
| Soleus Capital Management, L.P. | 100,000 | $2,633 |
| Susquehanna Portfolio Strategies, LLC | 99,795 | $2,628 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 97,907 | $2,598 |
| XTX Topco Ltd | 93,469 | $2,461 |
| AQR CAPITAL MANAGEMENT LLC | 91,075 | $2,398 |
| BANK OF AMERICA CORP /DE/ | 89,524 | $2,357 |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 88,800 | $2,338 |
| ACUTA CAPITAL PARTNERS, LLC | 80,143 | $2,110 |
| BARCLAYS PLC | 79,966 | $2,106 |
| PANAGORA ASSET MANAGEMENT INC | 78,336 | $2,063 |
| NEOS Investment Management LLC | 77,115 | $2,030 |
| TEMA ETFS LLC | 75,975 | $2,000 |
| STIFEL FINANCIAL CORP | 75,847 | $1,997 |
| STATE OF WISCONSIN INVESTMENT BOARD | 75,566 | $1,990 |
| RHUMBLINE ADVISERS | 75,498 | $1,988 |
| Man Group plc | 75,318 | $1,983 |
| CREDIT AGRICOLE S A | 75,000 | $1,975 |
| Swiss National Bank | 74,200 | $1,954 |
| Pictet Asset Management Holding SA | 73,627 | $1,966 |
| JANE STREET GROUP, LLC | 70,445 | $1,855 |
| Fisher Asset Management, LLC | 68,197 | $1,796 |
| Penserra Capital Management LLC | 60,146 | $2 |
| FRANKLIN RESOURCES INC | 58,987 | $1,553 |
| AMERICAN CENTURY COMPANIES INC | 58,832 | $1,549 |
| Russell Investments Group, Ltd. | 58,350 | $1,536 |
| ROYAL BANK OF CANADA | 55,055 | $1,450 |
| ALLIANCEBERNSTEIN L.P. | 50,030 | $1,317 |
| Dana Investment Advisors, Inc. | 48,318 | $1,272 |
| SIMPLEX TRADING, LLC | 48,040 | $1,265 |
| MACKENZIE FINANCIAL CORP | 45,460 | $1,204 |
| North Growth Management Ltd. | 45,000 | $1 |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 43,052 | $1,134 |
| VICTORY CAPITAL MANAGEMENT INC | 42,905 | $1,130 |
| ENVESTNET ASSET MANAGEMENT INC | 40,812 | $1,075 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,761 | $994 |
| JPMORGAN CHASE & CO | 35,008 | $922 |
| TANG CAPITAL MANAGEMENT LLC | 34,631 | $912 |
| Campbell & CO Investment Adviser LLC | 33,588 | $884 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 32,815 | $864 |
| Legal & General Group Plc | 32,149 | $846 |
| SBI Okasan Asset Management Co.Ltd. | 32,000 | $856 |
| TWO SIGMA ADVISERS, LP | 31,415 | $827 |
| TUDOR INVESTMENT CORP ET AL | 30,324 | $798 |
| JOURNEY STRATEGIC WEALTH LLC | 29,050 | $765 |
| Quantinno Capital Management LP | 28,883 | $760 |
| 106 other institutions | 949,766 | $23,271 |