ZYMEWORKS INC

Ticker: ZYME CUSIP: 98985Y108 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2024

Shares 26,430 Value ($000) $278 Avg Close $11.10 Range $9.64 - $13.14

Q4 2023

Shares 36,300 Value ($000) $377 Avg Close $7.97 Range $6.01 - $10.99

Q3 2023

Shares 48,900 Value ($000) $310 Avg Close $7.39 Range $6.11 - $8.80

Q2 2023

Shares 59,200 Value ($000) $511 Avg Close $8.95 Range $7.75 - $10.35

Q1 2023

Shares 43,600 Value ($000) $394 Avg Close $8.72 Range $7.31 - $10.80

Q4 2022

Shares 37,712 Value ($000) $296 Avg Close $7.03 Range $4.86 - $9.28

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2024	26,430	$278	$11.10	$9.64 - $13.14
Q4 2023	36,300	$377	$7.97	$6.01 - $10.99
Q3 2023	48,900	$310	$7.39	$6.11 - $8.80
Q2 2023	59,200	$511	$8.95	$7.75 - $10.35
Q1 2023	43,600	$394	$8.72	$7.31 - $10.80
Q4 2022	37,712	$296	$7.03	$4.86 - $9.28