ZYMEWORKS INC

Ticker: ZYME CUSIP: 98985Y108 Class: Common Stock

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 12,225 Value ($000) $209 Avg Close $14.31 Range $11.51 - $17.60

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	12,225	$209	$14.31	$11.51 - $17.60