ZYMEWORKS INC

Ticker: ZYME CUSIP: 98985Y108 Class: Common Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 31,415 Value ($000) $827 Avg Close $21.81 Range $16.00 - $28.49

Q2 2023

Shares 13,200 Value ($000) $114 Avg Close $8.95 Range $7.75 - $10.35

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	31,415	$827	$21.81	$16.00 - $28.49
Q2 2023	13,200	$114	$8.95	$7.75 - $10.35