ZYMEWORKS INC

Ticker: ZYME CUSIP: 98985Y108 Class: Common Stock

Brevan Howard Capital Management LP's Holding History (CIK: 0001512857)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 23,333 Value ($000) $614 Avg Close $21.81 Range $16.00 - $28.49

Q3 2025

Shares 14,518 Value ($000) $248 Avg Close $14.31 Range $11.51 - $17.60

Q2 2025

Shares 10,628 Value ($000) $133 Avg Close $11.91 Range $9.03 - $13.44

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	23,333	$614	$21.81	$16.00 - $28.49
Q3 2025	14,518	$248	$14.31	$11.51 - $17.60
Q2 2025	10,628	$133	$11.91	$9.03 - $13.44